Reactome | NDUFB4 [mitochondrial inner membrane]

NDUFB4 [mitochondrial inner membrane]

Stable Identifier

R-HSA-59934

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase B15 subunit , Complex I-B15, CI-B15

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB4 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95168 NDUFB4

Gene Names

NDUFB4

Chain

initiator methionine:, chain:2-129

Reference Genes

BioGPS Gene:4710 NDUFB4

COSMIC (genes):NDUFB4 NDUFB4

CTD Gene:4710 NDUFB4

dbSNP Gene:4710 NDUFB4

ENSEMBL:ENSG00000065518 NDUFB4

ENSEMBL_homo_sapiens_GENE:ENSG00000065518.8 NDUFB4

HGNC:7699 NDUFB4

KEGG Gene (Homo sapiens):4710 NDUFB4

Monarch:4710 NDUFB4

NCBI Gene:4710 NDUFB4

OMIM:603840 NDUFB4

UCSC:O95168 NDUFB4

Reference Transcript

Other Identifiers

11718278_s_at

11745384_s_at

11760040_x_at

16944502

218226_PM_s_at

218226_s_at

228940_PM_at

228940_at

2638440

2638441

2638449

2638450

2638451

2638452

2638453

4047218

4047219

4047220

4047221

4047222

4047227

4047228

4710

65777_at

65778_at

8081945

8093314

A_23_P69468

GE61710

GE79271

GE87765

GO:0003824

GO:0005215

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0006979

GO:0007005

GO:0008137

GO:0009060

GO:0016020

GO:0016491

GO:0032981

GO:0042776

GO:0043226

GO:0055086

GO:0065003

GO:0070469

GO:1901135

HMNXSV003051864

Hs.227750.1.S1_3p_a_at

Hs.227750.1.S1_3p_x_at

ILMN_1668027

ILMN_1721719

ILMN_2081863

PH_hs_0012660

PH_hs_0026966

TC03000617.hg

g6041668_3p_a_at

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ndufb4 [mitochondrial inner membrane] (Xenopus tropicalis)

LOC103691107 [mitochondrial inner membrane] (Rattus norvegicus)

nuo-6 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFB4 [mitochondrial inner membrane] (Bos taurus)

NDUFB4 [mitochondrial inner membrane] (Canis familiaris)

NDUFB4 [mitochondrial inner membrane] (Gallus gallus)

NDUFB4 [mitochondrial inner membrane] (Sus scrofa)

Ndufb4 [mitochondrial inner membrane] (Mus musculus)

ND-B15 [mitochondrial inner membrane] (Drosophila melanogaster)

fj49f11 [mitochondrial inner membrane] (Danio rerio)

Cross References

RefSeq

NP_004538.2, NP_001161803.1

OpenTargets

ENSG00000065518

GeneCards

O95168

HPA

ENSG00000065518-NDUFB4

Ensembl

ENSP00000419578, ENST00000184266, ENSG00000065518, ENSP00000184266, ENST00000485064

PRO

O95168

Pharos - Targets

O95168

HMDB Protein

HMDBP00149

PDB

5XTD, 5XTH, 5XTI, 5XTC

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	5

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