SLC22A18 exchanges extracellular organic cations for cytosolic H+

Stable Identifier
R-HSA-597628
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ORCTL2 mediates the transport of chloroquine and quinidine with efflux of protons
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human gene SLC22A18 encodes organic cation transporter-like protein 2 (ORCTL2). It is expressed at high levels in kidney, liver and colon and at lower levels in heart, brain and lung. ORCTL2 can transport chloroquine and quinidine with the antiport of protons (Reece et al. 1998). Defects in SLC22A18 may play a role in tumorigenesis (Schwienbacher et al. 1998). How SLC22A18 might be involved in growth regulation is poorly understood. There is speculation that it may be involved in resistance to chemotherapy drugs and/or in the export of genotoxic substances whose retention may increase the risk of tumor formation.

Literature References
PubMed ID Title Journal Year
9744804 Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules

Reece, M, Prawitt, D, Landers, J, Kast, C, Gros, P, Housman, D, Zabel, BU, Pelletier, J

FEBS Lett 1998
9520460 Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples

Schwienbacher, C, Sabbioni, S, Campi, M, Veronese, A, Bernardi, G, Menegatti, A, Hatada, I, Mukai, T, Ohashi, H, Barbanti-Brodano, G, Croce, CM, Negrini, M

Proc Natl Acad Sci U S A 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
solute:proton antiporter activity of SLC22A18 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!