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MGMT [nucleoplasm]
Stable Identifier
R-HSA-59222
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O- methylguanine-DNA methyltransferase), Methylated-DNA--protein-cysteine methyltransferase , 6-O- methylguanine-DNA methyltransferase
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Reversal (Homo sapiens)
MGMT-mediated DNA damage reversal (Homo sapiens)
MGMT binds alkylated DNA containing 6-O-methylguanine (Homo sapiens)
MGMT:Zn2+ [nucleoplasm] (Homo sapiens)
MGMT [nucleoplasm] (Homo sapiens)
MGMT:Zn2+:6-OMeG-dsDNA [nucleoplasm] (Homo sapiens)
MGMT:Zn2+ [nucleoplasm] (Homo sapiens)
MGMT [nucleoplasm] (Homo sapiens)
MGMT/hAGT mediated DNA Damage Reversal (Homo sapiens)
MGMT:Zn2+ [nucleoplasm] (Homo sapiens)
MGMT [nucleoplasm] (Homo sapiens)
MGMT:Zn2+:6-OMeG-dsDNA [nucleoplasm] (Homo sapiens)
MGMT:Zn2+ [nucleoplasm] (Homo sapiens)
MGMT [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16455 MGMT
Gene Names
MGMT
Chain
chain:1-207
Reference Genes
BioGPS Gene:4255 MGMT
COSMIC (genes):MGMT MGMT
CTD Gene:4255 MGMT
dbSNP Gene:4255 MGMT
ENSEMBL:ENSG00000170430 MGMT
HGNC:7059 MGMT
Monarch:4255 MGMT
NCBI Gene:4255 MGMT
OMIM:156569 MGMT
UCSC:P16455 MGMT
Reference Transcript
RefSeq:XM_005252682.2 MGMT
RefSeq:NM_002412.4 MGMT
Other Identifiers
11720201_at
16710608
16710620
204880_PM_at
204880_at
2051_at
2052_g_at
3270841
3270862
3270863
3270864
3270865
3270881
3270885
3270886
3270902
3270916
3270917
3270918
3270919
3270920
3270921
3270922
3270923
3270924
3270925
3270926
3270927
3270928
3270934
3270966
3270968
3270970
3270972
3270974
3270976
3270978
3270979
3270980
3270981
3270982
3270983
3270984
4255
55762_at
7931379
A_14_P114979
A_23_P104323
GE520642
GE57913
GO:0003677
GO:0003824
GO:0003908
GO:0005634
GO:0005654
GO:0006259
GO:0006266
GO:0006281
GO:0006307
GO:0006974
GO:0008168
GO:0009008
GO:0016020
GO:0016740
GO:0032259
GO:0043066
GO:0043226
GO:0046872
GO:0140096
GO:0140097
GO:2000781
HMNXSV003019574
HMNXSV003051558
ILMN_1795639
M29971_at
PH_hs_0031945
TC10000927.hg
TC10000928.hg
g4505176_3p_at
p2133
Participates
as a component of
MGMT:Zn2+ [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MetC-MGMT [nucleoplasm]
Inferred To
MGMT [nucleoplasm]
(Bos taurus)
MGMT [nucleoplasm]
(Canis familiaris)
MGMT [nucleoplasm]
(Gallus gallus)
MGMT [nucleoplasm]
(Mus musculus)
MGMT [nucleoplasm]
(Rattus norvegicus)
MGMT [nucleoplasm]
(Sus scrofa)
mgmt [nucleoplasm]
(Danio rerio)
mgmt [nucleoplasm]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000498729
,
ENST00000651593
OpenTargets
ENSG00000170430
ZINC - Substances
MGMT_HUMAN
ZINC target
P16455
PRO
P16455
GlyGen
P16455
PDB
1T38
,
1T39
,
8RTY
,
1YFH
,
8RU2
,
1QNT
,
1EH8
,
1EH7
,
1EH6
,
8RGH
,
8RGG
ZINC - Investigational
MGMT_HUMAN
IntEnz
2.1.1.63
HPA
ENSG00000170430-MGMT
Pharos - Targets
P16455
Orphanet
MGMT
ZINC - Predictions - Purchasable
MGMT_HUMAN
HMDB Protein
HMDBP02029
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