Reactome | ITGB1 [plasma membrane]

ITGB1 [plasma membrane]

Stable Identifier

R-HSA-57596

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Integrin beta-1, Fibronectin receptor beta subunit, CD29 antigen, Integrin VLA-4 beta subunit

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Locations in the PathwayBrowser for interactor UniProt:P32927 CSF2RB

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External Reference Information

External Reference

UniProt:P05556 ITGB1

Gene Names

ITGB1, FNRB, MDF2, MSK12

Chain

signal peptide:1-20, chain:21-798

Reference Genes

BioGPS Gene:3688 ITGB1

COSMIC (genes):ITGB1 ITGB1

CTD Gene:3688 ITGB1

dbSNP Gene:3688 ITGB1

ENSEMBL:ENSG00000150093 ITGB1

ENSEMBL_homo_sapiens_GENE:ENSG00000150093.20 ITGB1

HGNC:6153 ITGB1

KEGG Gene (Homo sapiens):3688 ITGB1

Monarch:3688 ITGB1

NCBI Gene:3688 ITGB1

OMIM:135630 ITGB1

UCSC:P05556 ITGB1

Reference Transcript

Other Identifiers

11715728_a_at

11737219_a_at

11742048_at

11758189_s_at

11758276_s_at

1553530_PM_a_at

1553530_a_at

1553678_PM_a_at

1553678_a_at

2055_s_at

211945_PM_s_at

211945_s_at

215878_at

230930_PM_at

230930_at

32808_at

3284190

3284191

3284192

3284193

3284196

3284197

3284198

3284199

3284200

3284201

3284202

3284203

3284204

3284205

3284206

3284207

3284208

3284210

3284211

3284213

3284214

3284215

3284217

3284218

3284221

3284224

3284229

3284230

3284231

3284232

3284236

3284238

3284239

3284240

3284241

3284242

3284244

3284255

3284261

3688

3822874

3852837

3852838

3852839

55363_at

7932966

A_23_P104193

A_23_P104199

A_23_P97780

A_32_P95397

A_33_P3799692

GE61911

GE87716

GO:0000082

GO:0000132

GO:0000278

GO:0000287

GO:0001618

GO:0001701

GO:0001726

GO:0001968

GO:0002020

GO:0002042

GO:0002052

GO:0002376

GO:0003013

GO:0003779

GO:0005178

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005768

GO:0005886

GO:0005925

GO:0006909

GO:0006954

GO:0006968

GO:0007010

GO:0007155

GO:0007156

GO:0007159

GO:0007160

GO:0007161

GO:0007163

GO:0007229

GO:0007405

GO:0007517

GO:0007520

GO:0008092

GO:0008283

GO:0008305

GO:0008354

GO:0008542

GO:0009897

GO:0009986

GO:0010008

GO:0010710

GO:0010763

GO:0012501

GO:0014704

GO:0015026

GO:0016020

GO:0016192

GO:0016477

GO:0019960

GO:0021943

GO:0022414

GO:0023035

GO:0023052

GO:0030027

GO:0030030

GO:0030032

GO:0030154

GO:0030175

GO:0030182

GO:0030183

GO:0030198

GO:0030335

GO:0031175

GO:0031410

GO:0031589

GO:0031594

GO:0031623

GO:0032154

GO:0032587

GO:0033627

GO:0033631

GO:0034113

GO:0034330

GO:0034665

GO:0034666

GO:0034667

GO:0034668

GO:0034674

GO:0034677

GO:0034678

GO:0034679

GO:0034680

GO:0034681

GO:0034682

GO:0035024

GO:0035313

GO:0035633

GO:0035748

GO:0042060

GO:0042383

GO:0042470

GO:0042995

GO:0043065

GO:0043197

GO:0043226

GO:0043235

GO:0043236

GO:0043547

GO:0044877

GO:0045121

GO:0045202

GO:0045214

GO:0045296

GO:0045445

GO:0045665

GO:0045743

GO:0045766

GO:0045906

GO:0046718

GO:0046872

GO:0046982

GO:0048333

GO:0048471

GO:0048626

GO:0048675

GO:0048813

GO:0048856

GO:0048870

GO:0050804

GO:0050839

GO:0050877

GO:0050901

GO:0051726

GO:0051897

GO:0051951

GO:0055007

GO:0055037

GO:0055085

GO:0060089

GO:0060379

GO:0060912

GO:0070062

GO:0070161

GO:0071404

GO:0071711

GO:0072659

GO:0090303

GO:0097060

GO:0097386

GO:0098631

GO:0098639

GO:0098640

GO:0098685

GO:0098978

GO:0150003

GO:0150053

GO:0150103

GO:1900748

GO:1901979

GO:1903078

GO:1905806

GO:1990782

GO:2000811

HMNXSV003009653

HMNXSV003043131

Hs.287797.0.A1_3p_s_at

Hs.87549.0.A1_3p_at

Hs.87549.0.A1_3p_x_at

Hs2.287797.6.S1_3p_s_at

Hs2.287797.8.S1_3p_s_at

ILMN_1714820

ILMN_1723467

ILMN_1754233

ILMN_1784454

ILMN_1861057

ILMN_2244108

ILMN_2383934

PH_hs_0018911

PH_hs_0027353

TC10001163.hg

U33880_at

X07979_at

Participates

as a candidate of

as a member of

as a component of

as a protein marker of

keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)

as an input of

ILK interacts with beta-1 integrin (Homo sapiens)

as an output of

SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it (Homo sapiens)

Other forms of this molecule

ITGB1 [endosome membrane]

Inferred To

ITGB1 [plasma membrane] (Bos taurus)

ITGB1 [plasma membrane] (Caenorhabditis elegans)

ITGB1 [plasma membrane] (Canis familiaris)

ITGB1 [plasma membrane] (Gallus gallus)

ITGB1 [plasma membrane] (Rattus norvegicus)

ITGB1 [plasma membrane] (Sus scrofa)

Itgb1 [plasma membrane] (Mus musculus)

itgb1b [plasma membrane] (Danio rerio)

itgb1b.2 [plasma membrane] (Danio rerio)

itgb1 [plasma membrane] (Xenopus tropicalis)

mys [plasma membrane] (Drosophila melanogaster)

itgb1b.1 [plasma membrane] (Danio rerio)

Homologues of ITGB1 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_002202.2, NP_596867.1, NP_391988.1

Guide to Pharmacology - Targets

2455

OpenTargets

ENSG00000150093

HPA

ENSG00000150093-ITGB1

GeneCards

P05556

Ensembl

ENST00000678989, ENST00000677999, ENSP00000504205, ENST00000676460, ENSP00000504508, ENSP00000503538, ENSP00000398029, ENSP00000379350, ENST00000423113, ENST00000302278, ENST00000437302, ENST00000396033, ENSP00000503916, ENSP00000303351, ENSG00000150093, ENST00000417122, ENST00000678952, ENST00000677310, ENST00000676659, ENSP00000503546, ENSP00000504444, ENST00000678701, ENST00000678943, ENSP00000504641, ENST00000678766, ENSP00000404546, ENSP00000388694, ENSP00000502882, ENSP00000502979

PRO

P05556

Pharos - Targets

P05556

PDB

7CEB, 4WJK, 3VI4, 4WK4, 4WK2, 3T9K, 7NWL, 3VI3, 7NXD, 3G9W, 4WK0, 4DX9, 7CEC

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08648 ITGA5	2	ITGA5 [plasma membrane] (R-HSA-9857636) ITGA5(42-894) [plasma membrane] (R-HSA-202735)	0.908	9
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.819	6
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.745	12
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.69	4
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.678	4
UniProt:P17301 ITGA2	1	ITGA2 [plasma membrane] (R-HSA-57562)	0.678	5
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.662	7
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.643	3
UniProt:P78536 ADAM17	6	ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763) ADAM17(215-827) [Golgi membrane] (R-HSA-9662839) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(215-827) [plasma membrane] (R-HSA-9663048) ADAM17 [plasma membrane] (R-HSA-179878)	0.609	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.597	8
UniProt:P26039 Tln1	4	Tln1 [extracellular region] (R-MMU-350693) Tln1(1-432) [cytosol] (R-MMU-9855103) Tln1(433-2541) [cytosol] (R-MMU-9855172) Tln1 [cytosol] (R-MMU-9855035)	0.571	2
UniProt:Q9BYF1 ACE2	5	ACE2(18-805) [plasma membrane] (R-HSA-2022344) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480)	0.57	4
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	3
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.564	2
UniProt:P23229 ITGA6	1	ITGA6(24-1130) [plasma membrane] (R-HSA-204439)	0.564	2
UniProt:Q13387-4 MAPK8IP2			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:O60784-2 TOM1			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9Y490 TLN1	4	TLN1 [extracellular region] (R-HSA-350693) TLN1(434-2541) [cytosol] (R-HSA-9855156) TLN1(1-433) [cytosol] (R-HSA-9855031) TLN1 [cytosol] (R-HSA-350713)	0.544	2
UniProt:P32927 CSF2RB	6	CSF2RB S271L [plasma membrane] (R-HSA-5688879) p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863)	0.544	5
UniProt:P48509 CD151	2	CD151 [cytosol] (R-HSA-446072) CD151 [plasma membrane] (R-HSA-913947)	0.527	2
UniProt:P17813 EGLN			0.524	3
UniProt:P78423 CX3CL1	1	CX3CL1 [extracellular region] (R-HSA-373368)	0.524	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.508	2
UniProt:Q9BY76 ANGPTL4	3	ANGPTL4 [extracellular region] (R-HSA-381271) ANGPTL4 [extracellular region] (R-HSA-6784897) ANGPTL4(164-406) [extracellular region] (R-HSA-9762251)	0.506	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9
UniProt:P05413 FABP3	1	FABP3 [cytosol] (R-HSA-5216066)	0.471	2
UniProt:P55290 CDH13	1	CDH13 [plasma membrane] (R-HSA-419009)	0.463	2
UniProt:P79114 MYO10			0.463	2
UniProt:P08962 CD63	3	CD63 [platelet dense granule membrane] (R-HSA-51683) CD63 [plasma membrane] (R-HSA-114583) CD63 [azurophil granule membrane] (R-HSA-6799157)	0.463	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2
UniProt:A0A0F6B5H5 A0A0F6B5H5			0.462	2

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