USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2

Stable Identifier
R-HSA-5697009
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP37 deubiquitinates Lys-11-linked polyubiquitin chains from cyclin-A (CCNA1 and CCNA2), which opposes the Lys-11-linked polyubiquitination mediated by the anaphase-promoting complex (APC/C) during G1/S transition, thereby promoting S phase entry. Phosphorylation by CDK2 at Ser-628 during G1/S phase maximizes USP37 deubiquitinase activity (Huang et al. 2011).

Literature References
PubMed ID Title Journal Year
21596315 Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry

Huang, X, Summers, MK, Pham, V, Lill, JR, Liu, J, Lee, G, Kirkpatrick, DS, Jackson, PK, Fang, G, Dixit, VM

Mol. Cell 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created