Reactome | USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2

USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2

Stable Identifier

R-HSA-5697009

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2

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USP37 deubiquitinates Lys-11-linked polyubiquitin chains from cyclin-A (CCNA1 and CCNA2), which opposes the Lys-11-linked polyubiquitination mediated by the anaphase-promoting complex (APC/C) during G1/S transition, thereby promoting S phase entry. Phosphorylation by CDK2 at Ser-628 during G1/S phase maximizes USP37 deubiquitinase activity (Huang et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21596315	Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry Kirkpatrick, DS, Huang, X, Lill, JR, Lee, G, Summers, MK, Fang, G, Liu, J, Jackson, PK, Dixit, VM, Pham, V	Mol. Cell	2011