USP37 deubiquitinates Lys-11-linked polyubiquitin chains from cyclin-A (CCNA1 and CCNA2), which opposes the Lys-11-linked polyubiquitination mediated by the anaphase-promoting complex (APC/C) during G1/S transition, thereby promoting S phase entry. Phosphorylation by CDK2 at Ser-628 during G1/S phase maximizes USP37 deubiquitinase activity (Huang et al. 2011).
Kirkpatrick, DS, Huang, X, Lill, JR, Lee, G, Summers, MK, Fang, G, Liu, J, Jackson, PK, Dixit, VM, Pham, V
thiol-dependent deubiquitinase activity of USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2 [nucleoplasm]
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