USP24 deubiquitinates DDB2

Stable Identifier
R-HSA-5696997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
USP24 deubiquitinates DDB2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

USP24 deubiquitinates DDB2, which is involved in the nucleotide excision repair pathway, preventing its proteasomal degradation (Zhang et al. 2012).

Literature References
PubMed ID Title Journal Year
23159851 The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability

Zhang, L, Lubin, A, Chen, H, Sun, Z, Gong, F

Cell Cycle 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP24:PolyUb-DDB2 [nucleoplasm]
Physical Entity
USP24:PolyUb-DDB2 [nucleoplasm]
Activity
thiol-dependent ubiquitin-specific protease activity (0004843)
Orthologous Events
USP24 deubiquitinates DDB2 (Danio rerio)
USP24 deubiquitinates DDB2 (Gallus gallus)
USP24 deubiquitinates DDB2 (Mus musculus)
USP24 deubiquitinates DDB2 (Rattus norvegicus)
USP24 deubiquitinates DDB2 (Sus scrofa)
USP24 deubiquitinates DDB2 (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-01)
Cite Us!