USP49 deubiquitinates H2B

Stable Identifier
R-HSA-5696960
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
USP49 deubiquitinates H2B
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

USP49 is a histone H2B-specific deubiquitinase that forms a complex with RuvB-like1 (RVB1) and PSMC5 (SUG1) (Zhang et al. 2013).

Literature References
PubMed ID Title Journal Year
23824326 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing

Zhang, Z, Jones, A, Joo, HY, Zhou, D, Cao, Y, Chen, S, Erdjument-Bromage, H, Renfrow, M, He, H, Tempst, P, Townes, TM, Giles, KE, Ma, L, Wang, H

Genes Dev. 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP49:Ub-histone H2B [nucleoplasm]
Physical Entity
USP49:Ub-histone H2B [nucleoplasm]
Activity
thiol-dependent ubiquitinyl hydrolase activity (0036459)
Orthologous Events
USP49 deubiquitinates H2B (Bos taurus)
USP49 deubiquitinates H2B (Caenorhabditis elegans)
USP49 deubiquitinates H2B (Canis familiaris)
USP49 deubiquitinates H2B (Danio rerio)
USP49 deubiquitinates H2B (Dictyostelium discoideum)
USP49 deubiquitinates H2B (Gallus gallus)
USP49 deubiquitinates H2B (Plasmodium falciparum)
USP49 deubiquitinates H2B (Sus scrofa)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-01)