USP49 deubiquitinates H2B

Stable Identifier
R-HSA-5696960
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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USP49 deubiquitinates H2B
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USP49 is a histone H2B-specific deubiquitinase that forms a complex with RuvB-like1 (RVB1) and PSMC5 (SUG1) (Zhang et al. 2013).
Literature References
PubMed ID Title Journal Year
23824326 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing

Zhang, Z, Jones, A, Joo, HY, Zhou, D, Cao, Y, Chen, S, Erdjument-Bromage, H, Renfrow, M, He, H, Tempst, P, Townes, TM, Giles, KE, Ma, L, Wang, H

Genes Dev. 2013
Participants
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Output
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as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of USP49:Ub-histone H2B [nucleoplasm]

Physical Entity
USP49:Ub-histone H2B [nucleoplasm] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP49 deubiquitinates H2B (Bos taurus)
USP49 deubiquitinates H2B (Canis familiaris)
USP49 deubiquitinates H2B (Danio rerio)
USP49 deubiquitinates H2B (Gallus gallus)
USP49 deubiquitinates H2B (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-01)
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