USP49 deubiquitinates H2B

Stable Identifier
R-HSA-5696960
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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USP49 deubiquitinates H2B
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USP49 is a histone H2B-specific deubiquitinase that forms a complex with RuvB-like1 (RVB1) and PSMC5 (SUG1) (Zhang et al. 2013).

Literature References
PubMed ID Title Journal Year
23824326 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing

Ma, L, Chen, S, Jones, A, Renfrow, M, Tempst, P, Joo, HY, Townes, TM, Erdjument-Bromage, H, Giles, KE, He, H, Zhou, D, Zhang, Z, Cao, Y, Wang, H

Genes Dev. 2013
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Catalyst Activity

thiol-dependent deubiquitinase activity of USP49:Ub-histone H2B [nucleoplasm]

Physical Entity
USP49:Ub-histone H2B [nucleoplasm] (Homo sapiens)
Activity
thiol-dependent deubiquitinase (GO:0004843)
Orthologous Events
USP49 deubiquitinates H2B (Caenorhabditis elegans)
USP49 deubiquitinates H2B (Danio rerio)
USP49 deubiquitinates H2B (Dictyostelium discoideum)
USP49 deubiquitinates H2B (Gallus gallus)
USP49 deubiquitinates H2B (Sus scrofa)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-01)
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