USP49 deubiquitinates H2B

Stable Identifier
R-HSA-5696960
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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USP49 deubiquitinates H2B
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USP49 is a histone H2B-specific deubiquitinase that forms a complex with RuvB-like1 (RVB1) and PSMC5 (SUG1) (Zhang et al. 2013).

Literature References
PubMed ID Title Journal Year
23824326 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing

Zhang, Z, Jones, A, Joo, HY, Zhou, D, Cao, Y, Chen, S, Erdjument-Bromage, H, Renfrow, M, He, H, Tempst, P, Townes, TM, Giles, KE, Ma, L, Wang, H

Genes Dev. 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP49:Ub-histone H2B [nucleoplasm]
Physical Entity
USP49:Ub-histone H2B [nucleoplasm]
Activity
thiol-dependent ubiquitin-specific protease activity (0004843)
Orthologous Events
USP49 deubiquitinates H2B (Caenorhabditis elegans)
USP49 deubiquitinates H2B (Canis familiaris)
USP49 deubiquitinates H2B (Danio rerio)
USP49 deubiquitinates H2B (Dictyostelium discoideum)
USP49 deubiquitinates H2B (Gallus gallus)
USP49 deubiquitinates H2B (Plasmodium falciparum)
USP49 deubiquitinates H2B (Sus scrofa)
USP49 deubiquitinates H2B (Xenopus tropicalis)
Cross References
Target Pathogen
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-01)
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