Reactome | USP44 deubiquitinates CDC20

USP44 deubiquitinates CDC20

Stable Identifier

R-HSA-5696958

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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USP44 specifically mediates the deubiquitination of CDC20, which promotes the association of MAD2L1 and CDC20, which in turn increases the stabilty of the MAD2L1-CDC20-APC/C ternary complex (Mitotic Checkpoint Complex), thereby preventing premature activation of the Anaphase Promoting Complex/Cyclosome (APC/C) (Stegmeier et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17443180	Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities Sowa, ME, Kirschner, MW, Rape, M, McDonald ER, 3rd, Sorger, PK, Li, MZ, Elledge, SJ, Hannon, GJ, Nalepa, G, Ang, XL, Draviam, VM, Stegmeier, F, Harper, JW	Nature	2007