USP44 specifically mediates the deubiquitination of CDC20, which promotes the association of MAD2L1 and CDC20, which in turn increases the stabilty of the MAD2L1-CDC20-APC/C ternary complex (Mitotic Checkpoint Complex), thereby preventing premature activation of the Anaphase Promoting Complex/Cyclosome (APC/C) (Stegmeier et al. 2007).
Stegmeier, F, Rape, M, Draviam, VM, Nalepa, G, Sowa, ME, Ang, XL, McDonald ER, 3rd, Li, MZ, Hannon, GJ, Sorger, PK, Kirschner, MW, Harper, JW, Elledge, SJ
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