USP44 deubiquitinates CDC20

Stable Identifier
R-HSA-5696958
Type
Reaction
Species
Homo sapiens
Compartment
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USP44 specifically mediates the deubiquitination of CDC20, which promotes the association of MAD2L1 and CDC20, which in turn increases the stabilty of the MAD2L1-CDC20-APC/C ternary complex (Mitotic Checkpoint Complex), thereby preventing premature activation of the Anaphase Promoting Complex/Cyclosome (APC/C) (Stegmeier et al. 2007).

Literature References
PubMed ID Title Journal Year
17443180 Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

Sowa, ME, Kirschner, MW, Rape, M, McDonald ER, 3rd, Sorger, PK, Li, MZ, Elledge, SJ, Hannon, GJ, Nalepa, G, Ang, XL, Draviam, VM, Stegmeier, F, Harper, JW

Nature 2007
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP44:PolyUb-CDC20 [nucleoplasm]

Orthologous Events
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