USP44 deubiquitinates CDC20

Stable Identifier
R-HSA-5696958
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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USP44 specifically mediates the deubiquitination of CDC20, which promotes the association of MAD2L1 and CDC20, which in turn increases the stabilty of the MAD2L1-CDC20-APC/C ternary complex (Mitotic Checkpoint Complex), thereby preventing premature activation of the Anaphase Promoting Complex/Cyclosome (APC/C) (Stegmeier et al. 2007).

Literature References
PubMed ID Title Journal Year
17443180 Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

Stegmeier, F, Rape, M, Draviam, VM, Nalepa, G, Sowa, ME, Ang, XL, McDonald ER, 3rd, Li, MZ, Hannon, GJ, Sorger, PK, Kirschner, MW, Harper, JW, Elledge, SJ

Nature 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP44:PolyUb-CDC20 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created