Reactome | USP33 deubiquitinates CCP110,ARRB

USP33 deubiquitinates CCP110,ARRB

Stable Identifier

R-HSA-5696945

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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USP33 regulates centrosome duplication by mediating deubiquitination and stabilization of CCP110 in S and G2/M phase (Li et al. 2013) and regulates G-protein coupled receptor (GPCR) signaling by deubiquitinating beta-arrestins (ARRB1 and ARRB2) (Shenoy et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
23486064	USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110 Seeley, ES, Dynlacht, BD, Fu, W, Li, J, D'Angiolella, V, Kobayashi, T, Pagano, M, Kim, S, Campos, EI	Nature	2013
19363159	Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2 Shenoy, SK, Ahn, S, Berthouze, M, Shukla, AK, Wilkinson, KD, Lefkowitz, RJ, Xiao, K, Modi, AS, Miller, WE	Proc. Natl. Acad. Sci. U.S.A.	2009