USP33 deubiquitinates CCP110,ARRB

Stable Identifier
R-HSA-5696945
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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USP33 regulates centrosome duplication by mediating deubiquitination and stabilization of CCP110 in S and G2/M phase (Li et al. 2013) and regulates G-protein coupled receptor (GPCR) signaling by deubiquitinating beta-arrestins (ARRB1 and ARRB2) (Shenoy et al. 2009).
Literature References
PubMed ID Title Journal Year
23486064 USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

Seeley, ES, Dynlacht, BD, Fu, W, Li, J, D'Angiolella, V, Kobayashi, T, Pagano, M, Kim, S, Campos, EI

Nature 2013
19363159 Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

Shenoy, SK, Ahn, S, Berthouze, M, Shukla, AK, Wilkinson, KD, Lefkowitz, RJ, Xiao, K, Modi, AS, Miller, WE

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Participates
Catalyst Activity

cysteine-type deubiquitinase activity of USP33:PolyUb-CCP110,PolyUb-ARRB1,PolyUb-ARRB2 [cytosol]

Orthologous Events
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Reviewed
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