Reactome | WDR20 [nucleoplasm]

WDR20 [nucleoplasm]

Stable Identifier

R-HSA-5696932

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

WD repeat-containing protein 20, WDR20_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP12, USP26 deubiquitinate AR (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20 [nucleoplasm] (Homo sapiens)
        
        WDR20 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26:AR [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20 [nucleoplasm] (Homo sapiens)
        
        WDR20 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26:PolyUb-AR [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20 [nucleoplasm] (Homo sapiens)
        
        WDR20 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TBZ3 WDR20

Gene Names

WDR20

Chain

initiator methionine:, chain:2-569

Reference Genes

BioGPS Gene:91833 WDR20

COSMIC (genes):WDR20 WDR20

CTD Gene:91833 WDR20

dbSNP Gene:91833 WDR20

ENSEMBL:ENSG00000140153 WDR20

HGNC:19667 WDR20

KEGG:hsa:91833 WDR20

Monarch:91833 WDR20

NCBI Gene:91833 WDR20

OMIM:617741 WDR20

UCSC:Q8TBZ3 WDR20

Reference Transcript

Participates

as a component of

USP12:WDR48:WDR20 [nucleoplasm] (Homo sapiens)

Inferred To

WDR20 [nucleoplasm] (Bos taurus)

WDR20 [nucleoplasm] (Canis familiaris)

WDR20 [nucleoplasm] (Dictyostelium discoideum)

WDR20 [nucleoplasm] (Gallus gallus)

WDR20 [nucleoplasm] (Sus scrofa)

bun62 [nucleoplasm] (Schizosaccharomyces pombe)

Wdr20 [nucleoplasm] (Drosophila melanogaster)

Wdr20 [nucleoplasm] (Mus musculus)

Wdr20 [nucleoplasm] (Rattus norvegicus)

wdr-20 [nucleoplasm] (Caenorhabditis elegans)

wdr20 [nucleoplasm] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000140153

ENSEMBL

ENSP00000335434, ENST00000299135, ENSP00000314209, ENSP00000406084, ENST00000555879, ENST00000342702, ENST00000335263, ENST00000556807, ENSP00000299135, ENSP00000452470, ENST00000454394, ENSP00000341037, ENST00000322340, ENSP00000450636, ENSP00000451633, ENST00000556511, ENSG00000140153

HPA

ENSG00000140153-WDR20

GeneCards

WDR20

PRO

Q8TBZ3

Pharos - Targets

Q8TBZ3

PDB

5K19, 5K1C, 6JLQ

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TAF3 WDR48	3	WDR48 [nucleoplasm] (R-HSA-419549) WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673617) p-12Y-WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673645)	0.643	5
UniProt:Q9UN19 DAPP1	2	p-Y139-DAPP1 [plasma membrane] (R-HSA-1112650) DAPP1 [cytosol] (R-HSA-197950)	0.57	3
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.527	2

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