Reactome | USP28 deubiquitinates CLSPN and MYC

USP28 deubiquitinates CLSPN and MYC

Stable Identifier

R-HSA-5696914

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

USP28 is Involved in DNA damage induced apoptosis by specifically stabilizing and deubiquitinating proteins of the DNA damage pathway including CLSPN (Zhang et al. 2006). It also binds to the nucleoplasmic alpha isoform of Fbw7, counteracting FBW7 ubiquitin ligase activity by deubiquitinating MYC in the nucleoplasm, which reduces MYC proteasomal degradation (Popov et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
16901786	A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response Zhang, D, Zaugg, K, Mak, TW, Elledge, SJ	Cell	2006
17873522	Fbw7 and Usp28 regulate myc protein stability in response to DNA damage Popov, N, Herold, S, Llamazares, M, Schülein, C, Eilers, M	Cell Cycle	2007