AKR1B15 reduces EST17b to E1

Stable Identifier
R-HSA-5696822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The aldo-keto reductases (AKRs) are multifunctional enzymes that catalyse the reduction of biogenic and xenobiotic aldehydes and ketones as well as the synthesis and metabolism of sex hormones. The newest identified member, Aldo-keto reductase family 1 member B15 (AKR1B15) is able to catalyse the reduction of 17beta-sex hormones such as 17beta-estradiol (EST17b) to estrone (E1). Two isoforms of AKR1B15 exist in different subcellular locations; isoform 2 is cytosolic (like most AKRs) whereas isoform 1 co-localises with the mitochondria (Weber et al. 2015).

Literature References
PubMed ID Title Journal Year
25577493 Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates

Weber, S, Salabei, JK, Moller, G, Kremmer, E, Bhatnagar, A, Adamski, J, Barski, OA

J. Biol. Chem. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
estradiol 17-beta-dehydrogenase activity of AKR1B15 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
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