tRNA ligase complex ligates tRNA exons

Stable Identifier
R-HSA-5696816
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The RNA ligase complex ligates tRNA exons yielding intact, spliced tRNAs (Popow et al. 2011, Popow et al. 2014). The reaction apparently occurs in one step with no residual 2' phosphate that requires removal, as in yeast.

Literature References
PubMed ID Title Journal Year
24870230 Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

Popow, J, Jurkin, J, Schleiffer, A, Martinez, J

Nature 2014
21311021 HSPC117 is the essential subunit of a human tRNA splicing ligase complex

Popow, J, Englert, M, Weitzer, S, Schleiffer, A, Mierzwa, B, Mechtler, K, Trowitzsch, S, Will, CL, Lührmann, R, Söll, D, Martinez, J

Science 2011
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
RNA ligase (ATP) activity of tRNA ligase complex [nucleoplasm]
Physical Entity
Activity
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Created