ELAC2 cleaves the 3' end of pre-tRNA

Stable Identifier
R-HSA-5696815
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ELAC2, a RNaseZ activity in humans, endonucleolytically cleaves pre-tRNAs near the 3' end, generating a 3' hydroxyl group to which the nucleotides CCA will be polymerized (Takaku et al. 2004, Yan et al. 2006, Elbarbary et al. 2008). ELAC2 is located in both the nucleus and mitochondria (Brzezniak et al. 2011). ELAC1, a homologue of ELAC2, is located in the cytosol (Rossmanith 2011) and cleaves 3' ends of tRNAs in vitro (Takaku et al. 2003).

Participants
Participates
Event Information
Go Biological Process
Catalyst Activity

tRNA-specific ribonuclease activity of ELAC2 [nucleoplasm]

Authored
Reviewed
Created
Cite Us!