TSEN complex cleaves the intron from pre-tRNA

Stable Identifier
R-HSA-5696813
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TSEN complex cleaves the intron from pre-tRNA
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The TSEN complex endonucleolytically cleaves 5' and 3' of introns in tRNAs, leaving a 2',3' cyclic phosphate on the 5' exon and a 5' hydroxyl on the 3' exon (Paushkin et al. 2004, Trotta et al. 2006).

Literature References
PubMed ID Title Journal Year
15109492 Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation

Paushkin, SV, Peltz, SW, Patel, M, Furia, BS, Trotta, CR

Cell 2004
16710424 Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site

Paushkin, SV, Peltz, SW, Patel, M, Li, H, Trotta, CR

Nature 2006
Participants
Input
Output
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Event Information
Go Biological Process
tRNA splicing, via endonucleolytic cleavage and ligation (0006388)
Catalyst Activity

tRNA-specific ribonuclease activity of TSEN complex [nucleoplasm]

Physical Entity
TSEN complex [nucleoplasm] (Homo sapiens)
Activity
tRNA-specific ribonuclease activity (GO:0004549)
Authored
May, B  (2015-05-29)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-05-30)
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