TSEN complex cleaves the intron from pre-tRNA

Stable Identifier
R-HSA-5696813
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The TSEN complex endonucleolytically cleaves 5' and 3' of introns in tRNAs, leaving a 2',3' cyclic phosphate on the 5' exon and a 5' hydroxyl on the 3' exon (Paushkin et al. 2004, Trotta et al. 2006).

Literature References
PubMed ID Title Journal Year
16710424 Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site

Trotta, CR, Paushkin, SV, Patel, M, Li, H, Peltz, SW

Nature 2006
15109492 Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation

Paushkin, SV, Patel, M, Furia, BS, Peltz, SW, Trotta, CR

Cell 2004
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
tRNA-specific ribonuclease activity of TSEN complex [nucleoplasm]
Physical Entity
Activity
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