Reactome | RTCB [nucleoplasm]

RTCB [nucleoplasm]

Stable Identifier

R-HSA-5696792

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="2"tRNA-splicing ligase RtcB homolog ecNumber evidence="2"6.5.1.3/ecNumber, RTCB_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y3I0 RTCB

Gene Names

RTCB, C22orf28, HSPC117

Chain

chain:1-505

Reference Genes

BioGPS Gene:51493 RTCB

COSMIC (genes):RTCB RTCB

CTD Gene:51493 RTCB

dbSNP Gene:51493 RTCB

ENSEMBL:ENSG00000100220 RTCB

HGNC:26935 RTCB

Monarch:51493 RTCB

NCBI Gene:51493 RTCB

OMIM:613901 RTCB

UCSC:Q9Y3I0 RTCB

Reference Transcript

RefSeq:NM_014306.4 RTCB

Other Identifiers

11715645_s_at

11749368_a_at

11751754_a_at

11752603_a_at

11752604_s_at

16655165

16655167

16655169

16655171

16655185

16655187

16655189

16655191

16655193

16655195

16655203

16655205

16655207

16655209

16655211

16655213

16655215

16655217

16934227

18671579

18671580

18671581

18671582

18671583

18671584

18671585

18671586

18671587

18671588

18671589

18671590

18671591

18671592

18671593

18671594

18671595

18671596

18671597

200042_PM_at

200042_at

38689_at

3958254

3958255

3958258

3958261

3958262

3958263

3958266

3958267

3958269

3958270

3958272

3958273

3958276

3958277

3958278

3958279

3958281

3958282

3958283

3958335

3958337

3958339

3958341

3958343

3958355

3958389

3958391

3958393

3958395

3958397

3958399

51493

7892567

7892757

7893297

7893619

7893699

7893700

7893816

7894188

7894458

7894686

7894820

7894903

7895016

7895031

7895040

7895090

7895566

7895631

7895846

7895858

7895967

7896069

7896324

7896469

7896495

7896608

8075585

A_23_P68889

A_23_P68892

GE60554

GO:0001701

GO:0001890

GO:0003723

GO:0003824

GO:0003972

GO:0005515

GO:0005525

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005789

GO:0005829

GO:0006388

GO:0006396

GO:0006399

GO:0008033

GO:0008092

GO:0008452

GO:0016874

GO:0016886

GO:0017166

GO:0043226

GO:0043231

GO:0046872

GO:0048856

GO:0072669

GO:0140098

GO:0170057

HMNXSV003009254

ILMN_1795991

PH_hs_0023368

TC22000682.hg

g7657014_3p_at

Participates

as a component of

tRNA ligase complex [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENST00000216038, ENSP00000216038

OpenTargets

ENSG00000100220

IntEnz

6.5.1.8

HPA

ENSG00000100220-RTCB

PRO

Q9Y3I0

Pharos - Targets

Q9Y3I0

GlyGen

Q9Y3I0

HMDB Protein

HMDBP11927

PDB

7P3B, 8BTT, 8ODP, 8ODO

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.57	3
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.527	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.488	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.462	3