Reactome | DDB1:PAR-DDB2 [nucleoplasm]

DDB1:PAR-DDB2 [nucleoplasm]

Stable Identifier

R-HSA-5696680

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PAR-UV-DDB

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - DNA Damage Recognition in GG-NER (Homo sapiens)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
    - Dual Incision in GG-NER (Homo sapiens)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
      - CHD1L is recruited to GG-NER site (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
      - Formation of the pre-incision complex in GG-NER (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
      - RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
      - Recruitment of XPA and release of CAK (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
      - TFIIH binds GG-NER site to form a verification complex (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
19109893	Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex Scrima, A, Konícková, R, Czyzewski, BK, Kawasaki, Y, Jeffrey, PD, Groisman, R, Nakatani, Y, Iwai, S, Pavletich, NP, Thomä, NH	Cell	2008