Reactome | CHD1L is recruited to GG-NER site

CHD1L is recruited to GG-NER site

Stable Identifier

R-HSA-5696670

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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A chromatin remodeling enzyme CHD1L (ALC1) is recruited to DNA damage sites through interaction with PARylated PARP1 (or possibly PARP2) (Ahel et al. 2009) or PARylated DDB2 (Pines et al. 2012). CHD1L catalyzes PARP-stimulated nucleosome sliding and is needed for efficient PARP-dependent DNA repair (Ahel et al. 2009). CHD1L depletion or PARP inhibition impair global genomic nucleotide excision repair (GG-NER) of UV-induced DNA damage (Pines et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
19661379	Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1 Ahel, D, Horejsí, Z, Wiechens, N, Polo, SE, Garcia-Wilson, E, Ahel, I, Flynn, H, Skehel, M, West, SC, Jackson, SP, Owen-Hughes, T, Boulton, SJ	Science	2009
23045548	PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1 Pines, A, Vrouwe, MG, Marteijn, JA, Typas, D, Luijsterburg, MS, Cansoy, M, Hensbergen, P, Deelder, A, de Groot, A, Matsumoto, S, Sugasawa, K, Thoma, N, Vermeulen, W, Vrieling, H, Mullenders, L	J. Cell Biol.	2012