PARP1 or PARP2 PARylates DDB2 and autoPARylates

Stable Identifier
R-HSA-5696655
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PARP1 and/or PARP2 homo- or heterodimers recruited to global genomic nucleotide excision repair (GG-NER) site poly(ADP)ribosylate (PARylate) DDB2 and also progressively autoPARylate. PARylation promotes retention of DDB2 at DNA damage sites (Pines et al. 2012, Robu et al. 2013).

Literature References
PubMed ID Title Journal Year
23045548 PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

Pines, A, Vrouwe, MG, Marteijn, JA, Typas, D, Luijsterburg, MS, Cansoy, M, Hensbergen, P, Deelder, A, de Groot, A, Matsumoto, S, Sugasawa, K, Thoma, N, Vermeulen, W, Vrieling, H, Mullenders, L

J. Cell Biol. 2012
23319653 Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair

Robu, M, Shah, RG, Petitclerc, N, Brind'Amour, J, Kandan-Kulangara, F, Shah, GM

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created