USP12, USP26 deubiquitinate AR

Stable Identifier
R-HSA-5696605
Type
Reaction
Species
Homo sapiens
Compartment
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USP12 (as part of a complex with WDR48 and WDR20) and USP26 can bind the androgen receptor and promote its deubiquitination (Faus et al. 2005, Burska et al. 2013, Dirac & Bernards 2010). USP26 is specifically expressed in testis tissue and is a potential infertility gene (Stouffs et al. 2005).

Literature References
PubMed ID Title Journal Year
20501646 The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling

Bernards, R, Dirac, AM

Mol. Cancer Res. 2010
24056413 Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor

Gaughan, L, O'Neill, D, Logan, IR, Harle, VJ, Burska, UL, Robson, CN, Coffey, K, Ramsey, H, Darby, S

J. Biol. Chem. 2013
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP12:WDR48:WDR20,USP26:PolyUb-AR [nucleoplasm]

Orthologous Events
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