Reactome | USP12, USP26 deubiquitinate AR

USP12, USP26 deubiquitinate AR

Stable Identifier

R-HSA-5696605

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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USP12 (as part of a complex with WDR48 and WDR20) and USP26 can bind the androgen receptor and promote its deubiquitination (Faus et al. 2005, Burska et al. 2013, Dirac & Bernards 2010). USP26 is specifically expressed in testis tissue and is a potential infertility gene (Stouffs et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
20501646	The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling Bernards, R, Dirac, AM	Mol. Cancer Res.	2010
24056413	Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor Gaughan, L, O'Neill, D, Logan, IR, Harle, VJ, Burska, UL, Robson, CN, Coffey, K, Ramsey, H, Darby, S	J. Biol. Chem.	2013