USP25 deubiquitinates DDX58

Stable Identifier
R-HSA-5696564
Type
Reaction [transition]
Species
Homo sapiens
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USP25, a negative regulator of the virus-triggered type I IFN signaling pathway, cleaves lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo from DDX58 (Retinoic acid-inducible gene I (RIG-I)), Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling (Zhong et al. 2013).

Literature References
PubMed ID Title Journal Year
24260525 Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling

Zhong, H, Wang, D, Fang, L, Zhang, H, Luo, R, Shang, M, Ouyang, C, Ouyang, H, Chen, H, Xiao, S

PLoS ONE 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP25:PolyUb-DDX58 [cytosol]
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Activity
Orthologous Events
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