USP25, a negative regulator of the virus-triggered type I IFN signaling pathway, cleaves lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo from DDX58 (Retinoic acid-inducible gene I (RIG-I)), Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling (Zhong et al. 2013).
Zhong, H, Chen, H, Shang, M, Ouyang, H, Ouyang, C, Fang, L, Luo, R, Zhang, H, Wang, D, Xiao, S
cysteine-type deubiquitinase activity of USP25:PolyUb-DDX58 [cytosol]
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