STAMBPL1 is a deubiquitinase

Stable Identifier
R-HSA-5696547
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
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STAMBPL1 is a deubiquitinase
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STAMBPL1 (AMSH-LP) has Lys-63 deubiquitinase activity (Sato et al. 2008) and positively regulates TGF-beta signaling (Ibarolla et al. 2004) but unlike STAMBP (AMSH1) it does not bind STAM (Kikuchi et al. 2003).

Literature References
PubMed ID Title Journal Year
18758443 Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

Sato, Y, Yoshikawa, A, Yamagata, A, Mimura, H, Yamashita, M, Ookata, K, Nureki, O, Iwai, K, Komada, M, Fukai, S

Nature 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of STAMBPL1 [cytosol]
Physical Entity
STAMBPL1 [cytosol]
Activity
Lys63-specific deubiquitinase activity (0061578)
This event is regulated
Positively by
Orthologous Events
STAMBPL1 is a deubiquitinase (Bos taurus)
STAMBPL1 is a deubiquitinase (Canis familiaris)
STAMBPL1 is a deubiquitinase (Danio rerio)
STAMBPL1 is a deubiquitinase (Dictyostelium discoideum)
STAMBPL1 is a deubiquitinase (Drosophila melanogaster)
STAMBPL1 is a deubiquitinase (Gallus gallus)
STAMBPL1 is a deubiquitinase (Mus musculus)
STAMBPL1 is a deubiquitinase (Rattus norvegicus)
STAMBPL1 is a deubiquitinase (Sus scrofa)
STAMBPL1 is a deubiquitinase (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-05-29)