STAMBPL1 is a deubiquitinase

Stable Identifier
R-HSA-5696547
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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STAMBPL1 is a deubiquitinase
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STAMBPL1 (AMSH-LP) has Lys-63 deubiquitinase activity (Sato et al. 2008) and positively regulates TGF-beta signaling (Ibarolla et al. 2004) but unlike STAMBP (AMSH1) it does not bind STAM (Kikuchi et al. 2003).
Literature References
PubMed ID Title Journal Year
18758443 Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

Yoshikawa, A, Yamashita, M, Komada, M, Iwai, K, Nureki, O, Ookata, K, Yamagata, A, Sato, Y, Fukai, S, Mimura, H

Nature 2008
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Output
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Catalyst Activity

K63-linked deubiquitinase activity of STAMBPL1 [cytosol]

Physical Entity
STAMBPL1 [cytosol] (Homo sapiens)
Activity
K63-linked deubiquitinase activity (GO:0061578)
This event is regulated
Positively by
Regulator
STAMBP:STAM [cytosol] (Homo sapiens)
Orthologous Events
STAMBPL1 is a deubiquitinase (Bos taurus)
STAMBPL1 is a deubiquitinase (Canis familiaris)
STAMBPL1 is a deubiquitinase (Dictyostelium discoideum)
STAMBPL1 is a deubiquitinase (Drosophila melanogaster)
STAMBPL1 is a deubiquitinase (Gallus gallus)
STAMBPL1 is a deubiquitinase (Mus musculus)
STAMBPL1 is a deubiquitinase (Rattus norvegicus)
STAMBPL1 is a deubiquitinase (Schizosaccharomyces pombe)
STAMBPL1 is a deubiquitinase (Sus scrofa)
STAMBPL1 is a deubiquitinase (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-05-29)
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