USP45 deubiquitinates ERCC1

Stable Identifier
R-HSA-5696465
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
USP45 deubiquitinates ERCC1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
USP45 ubiquitin protease, mutated in prostate cancer and B-cell lymphoma, deubiquitinates ERCC1. While the mechanism and timing of ERCC1 ubiquitination are not known, deubiquitination of ERCC1 by USP45 enables ERCC1 recruitment to DNA damage sites in nucleotide excision repair (NER) and repair of interstrand cross-links (ICLR) (Perez-Oliva et al. 2015).
Literature References
PubMed ID Title Journal Year
25538220 USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

Pérez-Oliva, AB, Lachaud, C, Szyniarowski, P, Muñoz, I, Macartney, T, Hickson, I, Rouse, J, Alessi, DR

EMBO J. 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of USP45 [nucleoplasm]

Physical Entity
USP45 [nucleoplasm] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP45 deubiquitinates ERCC1 (Bos taurus)
USP45 deubiquitinates ERCC1 (Danio rerio)
USP45 deubiquitinates ERCC1 (Mus musculus)
USP45 deubiquitinates ERCC1 (Rattus norvegicus)
USP45 deubiquitinates ERCC1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-05-04)
Reviewed
Fousteri, M  (2015-08-03)
Created
Orlic-Milacic, M  (2015-05-29)
Cite Us!