USP45 ubiquitin protease, mutated in prostate cancer and B-cell lymphoma, deubiquitinates ERCC1. While the mechanism and timing of ERCC1 ubiquitination are not known, deubiquitination of ERCC1 by USP45 enables ERCC1 recruitment to DNA damage sites in nucleotide excision repair (NER) and repair of interstrand cross-links (ICLR) (Perez-Oliva et al. 2015).
Hickson, I, Alessi, DR, Lachaud, C, Rouse, J, Szyniarowski, P, Macartney, T, Muñoz, I, Pérez-Oliva, AB
cysteine-type deubiquitinase activity of USP45 [nucleoplasm]
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