AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG

Stable Identifier
R-HSA-5696448
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Acyl-CoA wax alcohol acyltransferase 2 (AWAT2 aka MFAT) is an enzyme highly expressed in skin and thought to play an important role in lipid metabolism in skin. AWAT2 can transfer an acyl group from acyl-CoA to monoacylglycerol, long-chain alcohol, and retinol to form diacylglycerols, wax monoesters and retinyl esters, respectively. Human skin surface lipids are mainly composed of triacylglycerol and wax monoesters (Yen et al. 2005, Turkish et al. 2005).

Literature References
PubMed ID Title Journal Year
15671038 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily

Turkish, AR, Henneberry, AL, Cromley, D, Padamsee, M, Oelkers, P, Bazzi, H, Christiano, AM, Billheimer, JT, Sturley, SL

J. Biol. Chem. 2005
16106050 A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters

Yen, CL, Brown, CH, Monetti, M, Farese, RV

J. Lipid Res. 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
2-acylglycerol O-acyltransferase activity of AWAT2 [endoplasmic reticulum membrane]
Physical Entity
AWAT2 [endoplasmic reticulum membrane]
Activity
2-acylglycerol O-acyltransferase activity (0003846)
Orthologous Events
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Bos taurus)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Caenorhabditis elegans)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Canis familiaris)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Danio rerio)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Dictyostelium discoideum)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Gallus gallus)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Mus musculus)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Rattus norvegicus)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Saccharomyces cerevisiae)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Schizosaccharomyces pombe)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Sus scrofa)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Xenopus tropicalis)
Authored
Jassal, B  (2015-05-29)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-29)
Cite Us!