AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG

Stable Identifier
R-HSA-5696448
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Acyl-CoA wax alcohol acyltransferase 2 (AWAT2 aka MFAT) is an enzyme highly expressed in skin and thought to play an important role in lipid metabolism in skin. AWAT2 can transfer an acyl group from acyl-CoA to monoacylglycerol, long-chain alcohol, and retinol to form diacylglycerols, wax monoesters and retinyl esters, respectively. Human skin surface lipids are mainly composed of triacylglycerol and wax monoesters (Yen et al. 2005, Turkish et al. 2005).

Literature References
PubMed ID Title Journal Year
15671038 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily

Turkish, AR, Henneberry, AL, Cromley, D, Padamsee, M, Oelkers, P, Bazzi, H, Christiano, AM, Billheimer, JT, Sturley, SL

J. Biol. Chem. 2005
16106050 A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters

Yen, CL, Brown, CH, Monetti, M, Farese, RV

J. Lipid Res. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
2-acylglycerol O-acyltransferase activity of AWAT2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created