AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG

Stable Identifier
R-HSA-5696448
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG
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Acyl-CoA wax alcohol acyltransferase 2 (AWAT2 aka MFAT) is an enzyme highly expressed in skin and thought to play an important role in lipid metabolism in skin. AWAT2 can transfer an acyl group from acyl-CoA to monoacylglycerol, long-chain alcohol, and retinol to form diacylglycerols, wax monoesters and retinyl esters, respectively. Human skin surface lipids are mainly composed of triacylglycerol and wax monoesters (Yen et al. 2005, Turkish et al. 2005).

Literature References
PubMed ID Title Journal Year
16106050 A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters

Brown, CH, Farese, RV, Monetti, M, Yen, CL

J. Lipid Res. 2005
15671038 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily

Bazzi, H, Billheimer, JT, Cromley, D, Turkish, AR, Sturley, SL, Oelkers, P, Henneberry, AL, Padamsee, M, Christiano, AM

J. Biol. Chem. 2005
Participants
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Output
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as an event of
Catalyst Activity

2-acylglycerol O-acyltransferase activity of AWAT2 [endoplasmic reticulum membrane]

Physical Entity
AWAT2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
2-acylglycerol O-acyltransferase activity (GO:0003846)
Orthologous Events
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Bos taurus)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Caenorhabditis elegans)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Canis familiaris)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Danio rerio)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Dictyostelium discoideum)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Drosophila melanogaster)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Gallus gallus)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Mus musculus)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Rattus norvegicus)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Saccharomyces cerevisiae)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Schizosaccharomyces pombe)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Sus scrofa)
AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Xenopus tropicalis)
Authored
Jassal, B  (2015-05-29)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-29)
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