Reactome | AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters

AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters

Stable Identifier

R-HSA-5696424

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters

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Arachidyl alcohol (ARACOH) is straight-chain fatty alcohol of C20 length used as an emollient in cosmetics. Esterification of alcohols with fatty acids represents the formation of both storage and cytoprotective molecules in the body. Overproduction of these esters is associated with several disease pathologies, including atherosclerosis and obesity. The ER membrane-associated acyl-CoA wax alcohol acyltransferase 1 (AWAT1) mediates the esterification of its preferred substrate ARACOH (Turkish et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15671038	Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily Turkish, AR, Henneberry, AL, Cromley, D, Padamsee, M, Oelkers, P, Bazzi, H, Christiano, AM, Billheimer, JT, Sturley, SL	J. Biol. Chem.	2005