PXLP-K278-ETNPPL tetramer hydrolyses PETA

Stable Identifier
R-HSA-5696415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In mitochondria, ethanolamine-phosphate phospho-lyase and 5-phosphohydroxy-L-lysine phospho-lyase (ETNPPL and PHYKPL respectively) are two closely related pyridoxal-phosphate-dependent, homotetrameric ammoniophospholyases that hydrolyse phosphoethanolamine (PETA) and 5-phosphohydroxylysine (5PHL) respectively (Veiga-da-Cunha et al. 2012). PETA is a component and a precursor of phospholipids whereas 5PHL is a breakdown product of collagen. ETNPPL utilises one pyridoxal 5'-phosphate (PXLP) as cofactor per subunit.

Literature References
PubMed ID Title Journal Year
22241472 Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine

Veiga-da-Cunha, M, Hadi, F, Balligand, T, Stroobant, V, Van Schaftingen, E

J. Biol. Chem. 2012
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Catalyst Activity
Title
ethanolamine-phosphate phospho-lyase activity of PXLP-K278-ETNPPL tetramer [mitochondrial matrix]
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Activity
Orthologous Events
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Rhea
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