Reactome | LAIR2 binds collagen

LAIR2 binds collagen

Stable Identifier

R-HSA-5696357

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2 or CD306) a soluble homolog of LAIR1 protein, also has high affinity for various collagen molecules and this can interfere with collagen-dependent platelet aggregation and adhesion. LAIR-2 may function as a natural competitor for LAIR-1, thereby regulating its inhibitory potential (Lebbink et al. 2008, Lenting et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
18209062	The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction Raynal, N, Lenting, PJ, Lebbink, RJ, Jin, B, Meyaard, L, van Roon, JA, van den Berg, MC, de Ruiter, T	J. Immunol.	2008
20730098	Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member Denis, CV, Akkerman, JW, Lenting, PJ, Meyaard, L, Westerlaken, GH	PLoS ONE	2010