GSTO1 dimer reduces methylarsonate to methylarsonite

Stable Identifier
R-HSA-5696230
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GSTO1 dimer reduces methylarsonate to methylarsonite
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glutathione S-transferase omega-1 (GSTO1 aka monomethylarsonic acid reductase, MMA(V) reductase) is a bifunctional enzyme that has glutathione S-transferase activity and also takes part in the biotransformation of inorganic arsenic. It mediates the reduction of methylarsonate to methylarsonite (Zakharyan et al. 2001).

Literature References
PubMed ID Title Journal Year
11511179 Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily

Board, PG, Liebler, DC, Healy, SM, Aposhian, HV, Sampayo-Reyes, A, Zakharyan, RA, Tsaprailis, G

Chem. Res. Toxicol. 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

methylarsonate reductase activity of GSTO1 dimer [cytosol]

Physical Entity
GSTO1 dimer [cytosol] (Homo sapiens)
Activity
methylarsonate reductase activity (GO:0050610)
Orthologous Events
GSTO1 dimer reduces methylarsonate to methylarsonite (Bos taurus)
GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)
GSTO1 dimer reduces methylarsonate to methylarsonite (Canis familiaris)
GSTO1 dimer reduces methylarsonate to methylarsonite (Danio rerio)
GSTO1 dimer reduces methylarsonate to methylarsonite (Drosophila melanogaster)
GSTO1 dimer reduces methylarsonate to methylarsonite (Gallus gallus)
GSTO1 dimer reduces methylarsonate to methylarsonite (Mus musculus)
GSTO1 dimer reduces methylarsonate to methylarsonite (Rattus norvegicus)
GSTO1 dimer reduces methylarsonate to methylarsonite (Sus scrofa)
GSTO1 dimer reduces methylarsonate to methylarsonite (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-05-28)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-28)
Cite Us!