Reactome | AS3MT transfers CH3 from AdoMet to methylarsonite

AS3MT transfers CH3 from AdoMet to methylarsonite

Stable Identifier

R-HSA-5696213

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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AS3MT transfers CH3 from AdoMet to methylarsonite

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Arsenic is a groundwater contaminant and methylation is an important reaction in its biotransformation. The arsenite(3-) salt form can be methylated by arsenite methyltransferase (AS3MT), transfering a methyl group from the high energy donor S-adenosyl-L-methionine (AdoMet) (Wood et al. 2006). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate).

Literature References

PubMed ID	Title	Journal	Year
16407288	Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies Wood, TC, Salavagionne, OE, Mukherjee, B, Wang, L, Klumpp, AF, Thomae, BA, Eckloff, BW, Schaid, DJ, Wieben, ED, Weinshilboum, RM	J. Biol. Chem.	2006