AS3MT transfers CH3 from AdoMet to methylarsonite

Stable Identifier
R-HSA-5696213
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Arsenic is a groundwater contaminant and methylation is an important reaction in its biotransformation. The arsenite(3-) salt form can be methylated by arsenite methyltransferase (AS3MT), transfering a methyl group from the high energy donor S-adenosyl-L-methionine (AdoMet) (Wood et al. 2006). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate).

Literature References
PubMed ID Title Journal Year
16407288 Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies

Wood, TC, Salavagionne, OE, Mukherjee, B, Wang, L, Klumpp, AF, Thomae, BA, Eckloff, BW, Schaid, DJ, Wieben, ED, Weinshilboum, RM

J. Biol. Chem. 2006
Participants
Participates
Catalyst Activity

arsenite methyltransferase activity of AS3MT [cytosol]

Orthologous Events
Cross References
Rhea
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