Reactome | AOC3 deaminates BZAM

AOC3 deaminates BZAM

Stable Identifier

R-HSA-5696183

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Membrane primary amine oxidase (AOC3, aka vascular adhesion protein 1, VAP-1) is a membrane-bound, dimeric enzyme that can catalyse the oxidative deamination of primary amines such as benzylamine (BZAM) and methyalmine to their respective aldehydes (Kaitaniemi et al. 2009, Bour et al. 2007). It is widely expressed with highest expression in peripheral lymph nodes, hepatic endothelia, appendix, lung and small intestine (Smith et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9653080	Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule Bono, P, Jalkanen, S, Smith, DJ, Leu, T, Salmi, M, Hellman, J	J. Exp. Med.	1998
19588076	The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase Jalkanen, S, Elovaara, H, Grön, K, Salmi, M, Kaitaniemi, S, Elima, K, Liukkonen, J, Salminen, T, Kidron, H	Cell. Mol. Life Sci.	2009
17400359	Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes Saulnier-Blache, JS, Lefort, C, Wabitsch, M, Valet, P, Gres, S, Carpéné, C, Zorzano, A, Prévot, D, Daviaud, D, Bour, S	Biochimie	2007