Reactome | AGMO cleaves alkylglycerol into fatty aldehyde and glycerol

AGMO cleaves alkylglycerol into fatty aldehyde and glycerol

Stable Identifier

R-HSA-5696119

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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AGMO cleaves alkylglycerol into fatty aldehyde and glycerol

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Ether lipids (alkylglycerols, glyceryl ethers) are essential components of brain membranes, protect the eye from cataract, mediate signalling processes and are required for spermatogenesis. Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin-dependent protein and is the only enzyme known to cleave the ether bond of alkylglycerols and lyso-alkylglycerol phospholipids into fatty aldehydes and glycerol derivatives (Watschinger et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20643956	Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes Konrat, R, Lindner, HH, Hulo, N, Werner-Felmayer, G, Werner, ER, Hermann, M, Golderer, G, Keller, MA, Maglione, M, Hermetter, A, Sarg, B, Watschinger, K	Proc. Natl. Acad. Sci. U.S.A.	2010