ALDH8A1 oxidises 9cRAL to 9cRA

Stable Identifier
R-HSA-5696101
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ALDH8A1 oxidises 9cRAL to 9cRA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Aldehyde dehydrogenase family 8 member A1 (ALDH8A1, ALDH12) can preferentially mediate the oxidation of 9-cis-retinal (9cRAL) into the retinoid X receptor ligand 9-cis-retinoic acid (9cRA) (Lin & Napoli 2000). ALDH8A1 might function in the pathway of 9-cis-retinal metabolism.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

retinal dehydrogenase activity of ALDH8A1 [cytosol]

Physical Entity
ALDH8A1 [cytosol] (Homo sapiens)
Activity
retinal dehydrogenase activity (GO:0001758)
Orthologous Events
ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)
ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)
ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)
ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)
ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)
ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)
ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)
ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)
ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)
ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-05-27)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-27)
Cite Us!