ADPRM hydrolyses ADP-ribose to R5P and AMP

Stable Identifier
R-HSA-5696049
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ADPRM hydrolyses ADP-ribose to R5P and AMP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (ADPRM:Mn2+) can mediate the hydrolysis of ADP-ribose and less efficiently, CDP-alcohols and 2',3'-cAMP (Cabezas et al. 2015).

Literature References
PubMed ID Title Journal Year
25692488 Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase

López-Villamizar, I, Canales, J, Pinto, RM, Cameselle, JC, Ribeiro, JM, Costas, MJ, Fernández, A, Rodrigues, JR, Cabezas, A

PLoS ONE 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ADP-ribose diphosphatase activity of ADPRM:Mn2+ [cytosol]

Physical Entity
ADPRM:Mn2+ [cytosol] (Homo sapiens)
Activity
ADP-ribose diphosphatase activity (GO:0047631)
Orthologous Events
ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Mus musculus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-05-27)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-27)
Cite Us!