ADPRM hydrolyses ADP-ribose to R5P and AMP

Stable Identifier
R-HSA-5696049
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ADPRM hydrolyses ADP-ribose to R5P and AMP
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Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (ADPRM:Mn2+) can mediate the hydrolysis of ADP-ribose and less efficiently, CDP-alcohols and 2',3'-cAMP (Cabezas et al. 2015).
Literature References
PubMed ID Title Journal Year
25692488 Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase

López-Villamizar, I, Canales, J, Pinto, RM, Cameselle, JC, Ribeiro, JM, Costas, MJ, Fernández, A, Rodrigues, JR, Cabezas, A

PLoS ONE 2015
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Catalyst Activity

ADP-ribose diphosphatase activity of ADPRM:Mn2+ [cytosol]

Physical Entity
ADPRM:Mn2+ [cytosol] (Homo sapiens)
Activity
ADP-ribose diphosphatase activity (GO:0047631)
Orthologous Events
ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Mus musculus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-05-27)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-27)
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