ADPGK:Mg2+ phosphorylates Glc to G6P

Stable Identifier
R-HSA-5696021
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glucose phosphorylation is a central event in cellular metabolism. ADP-dependent glucokinase (ADPGK) can phosphorylate glucose (Glc) using ADP as the phosphate donor to glucose 6-phopshate (G6P). To date, it has not been established whether this phosphorylation supports a significant role in priming glucose for a metabolic fate other than glycolysis (Richter et al. 2012). Stdies of metabolic changes during T cell activation suggest a role for it there (Kaminski et al. 2012).

Literature References
PubMed ID Title Journal Year
22219026 Expression and role in glycolysis of human ADP-dependent glucokinase

Stowell, KM, Richter, S, Richter, JP, Sutherland-Smith, AJ, Mehta, SY, Wilson, WR, Ronimus, RS, Print, CG, Gribble, AM

Mol. Cell. Biochem. 2012
23168256 T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation

Gülow, K, Grigaravičius, P, Opp, S, Ruppert, T, Grudnik, P, Kamiński, MM, Gröne, HJ, Sauer, SW, Kamiński, M, Krammer, PH

Cell Rep 2012
Participants
Participates
Event Information
Catalyst Activity

ADP-specific glucokinase activity of ADPGK:Mg2+ [endoplasmic reticulum membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!