ADPGK:Mg2+ phosphorylates Glc to G6P

Stable Identifier
Homo sapiens
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Glucose phosphorylation is a central event in cellular metabolism. ADP-dependent glucokinase (ADPGK) can phosphorylate glucose (Glc) using ADP as the phosphate donor to glucose 6-phopshate (G6P). To date, it has not been established whether this phosphorylation supports a significant role in priming glucose for a metabolic fate other than glycolysis (Richter et al. 2012). Stdies of metabolic changes during T cell activation suggest a role for it there (Kaminski et al. 2012).

Literature References
PubMed ID Title Journal Year
22219026 Expression and role in glycolysis of human ADP-dependent glucokinase

Stowell, KM, Richter, S, Richter, JP, Sutherland-Smith, AJ, Mehta, SY, Wilson, WR, Ronimus, RS, Print, CG, Gribble, AM

Mol. Cell. Biochem. 2012
23168256 T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation

Gülow, K, Grigaravičius, P, Opp, S, Ruppert, T, Grudnik, P, Kamiński, MM, Gröne, HJ, Sauer, SW, Kamiński, M, Krammer, PH

Cell Rep 2012
Event Information
Catalyst Activity

ADP-specific glucokinase activity of ADPGK:Mg2+ [endoplasmic reticulum membrane]

Orthologous Events
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