Glucose phosphorylation is a central event in cellular metabolism. ADP-dependent glucokinase (ADPGK) can phosphorylate glucose (Glc) using ADP as the phosphate donor to glucose 6-phopshate (G6P). To date, it has not been established whether this phosphorylation supports a significant role in priming glucose for a metabolic fate other than glycolysis (Richter et al. 2012). Stdies of metabolic changes during T cell activation suggest a role for it there (Kaminski et al. 2012).
Stowell, KM, Richter, S, Richter, JP, Sutherland-Smith, AJ, Mehta, SY, Wilson, WR, Ronimus, RS, Print, CG, Gribble, AM
Gülow, K, Grigaravičius, P, Opp, S, Ruppert, T, Grudnik, P, Kamiński, MM, Gröne, HJ, Sauer, SW, Kamiński, M, Krammer, PH
ADP-specific glucokinase activity of ADPGK:Mg2+ [endoplasmic reticulum membrane]
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