Reactome | ADPGK:Mg2+ phosphorylates Glc to G6P

ADPGK:Mg2+ phosphorylates Glc to G6P

Stable Identifier

R-HSA-5696021

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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Glucose phosphorylation is a central event in cellular metabolism. ADP-dependent glucokinase (ADPGK) can phosphorylate glucose (Glc) using ADP as the phosphate donor to glucose 6-phosphate (G6P). To date, it has not been established whether this phosphorylation supports a significant role in priming glucose for a metabolic fate other than glycolysis (Richter et al. 2012). Studies of metabolic changes during T cell activation suggest a role for it there (Kaminski et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22219026	Expression and role in glycolysis of human ADP-dependent glucokinase Richter, S, Richter, JP, Mehta, SY, Gribble, AM, Sutherland-Smith, AJ, Stowell, KM, Print, CG, Ronimus, RS, Wilson, WR	Mol. Cell. Biochem.	2012
23168256	T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation Kamiński, MM, Sauer, SW, Kamiński, M, Opp, S, Ruppert, T, Grigaravičius, P, Grudnik, P, Gröne, HJ, Krammer, PH, Gülow, K	Cell Rep	2012