ACSF3 ligates CoA-SH to VLCFA

Stable Identifier
R-HSA-5696007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate
ReviewStatus
5/5
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ACSF3 ligates CoA-SH to VLCFA
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Acyl-coenzyme A synthetases (ACSs) catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid metabolism. Mitochondrial acyl-CoA synthetase family member 3 (ACSF3) preferentially ligates CoA-SH to very long-chain fatty acids (VLCFA), around C24 in length (Watkins et al. 2007).
Literature References
PubMed ID Title Journal Year
17762044 Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Watkins, PA, Maiguel, D, Jia, Z, Pevsner, J

J. Lipid Res. 2007
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as an event of
Catalyst Activity

very long-chain fatty acid-CoA ligase activity of ACSF3 [mitochondrial matrix]

Physical Entity
ACSF3 [mitochondrial matrix] (Homo sapiens)
Activity
very long-chain fatty acid-CoA ligase activity (GO:0031957)
Orthologous Events
ACSF3 ligates CoA-SH to VLCFA (Bos taurus)
ACSF3 ligates CoA-SH to VLCFA (Danio rerio)
ACSF3 ligates CoA-SH to VLCFA (Dictyostelium discoideum)
ACSF3 ligates CoA-SH to VLCFA (Drosophila melanogaster)
ACSF3 ligates CoA-SH to VLCFA (Mus musculus)
ACSF3 ligates CoA-SH to VLCFA (Rattus norvegicus)
ACSF3 ligates CoA-SH to VLCFA (Sus scrofa)
Cross References
RHEA
Authored
Jassal, B  (2015-05-26)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-26)
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