ACSF3 ligates CoA-SH to VLCFA

Stable Identifier
R-HSA-5696007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ACSF3 ligates CoA-SH to VLCFA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Acyl-coenzyme A synthetases (ACSs) catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid metabolism. Mitochondrial acyl-CoA synthetase family member 3 (ACSF3) preferentially ligates CoA-SH to very long-chain fatty acids (VLCFA), around C24 in length (Watkins et al. 2007).

Literature References
PubMed ID Title Journal Year
17762044 Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Pevsner, J, Jia, Z, Watkins, PA, Maiguel, D

J. Lipid Res. 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

very long-chain fatty acid-CoA ligase activity of ACSF3 [mitochondrial matrix]

Physical Entity
ACSF3 [mitochondrial matrix] (Homo sapiens)
Activity
very long-chain fatty acid-CoA ligase activity (GO:0031957)
Orthologous Events
ACSF3 ligates CoA-SH to VLCFA (Bos taurus)
ACSF3 ligates CoA-SH to VLCFA (Canis familiaris)
ACSF3 ligates CoA-SH to VLCFA (Danio rerio)
ACSF3 ligates CoA-SH to VLCFA (Dictyostelium discoideum)
ACSF3 ligates CoA-SH to VLCFA (Drosophila melanogaster)
ACSF3 ligates CoA-SH to VLCFA (Mus musculus)
ACSF3 ligates CoA-SH to VLCFA (Rattus norvegicus)
ACSF3 ligates CoA-SH to VLCFA (Sus scrofa)
Authored
Jassal, B  (2015-05-26)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-26)
Cite Us!