ACSF2 ligates CoA-SH to MCFA

Stable Identifier
R-HSA-5696004
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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ACSF2 ligates CoA-SH to MCFA
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Acyl-coenzyme A synthetases (ACSs) catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid metabolism. Mitochondrial acyl-CoA synthetase family member 2 (ACSF2) preferentially ligates CoA-SH to medium-chain fatty acids (MCFA), around C8 in length (Watkins et al. 2007).

Literature References
PubMed ID Title Journal Year
17762044 Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Pevsner, J, Jia, Z, Watkins, PA, Maiguel, D

J. Lipid Res. 2007
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Event Information
Go Biological Process
acyl-CoA metabolic process (0006637)
Catalyst Activity

long-chain fatty acid-CoA ligase activity of ACSF2 [mitochondrial matrix]

Physical Entity
ACSF2 [mitochondrial matrix] (Homo sapiens)
Activity
long-chain fatty acid-CoA ligase activity (GO:0004467)
Orthologous Events
ACSF2 ligates CoA-SH to MCFA (Bos taurus)
ACSF2 ligates CoA-SH to MCFA (Caenorhabditis elegans)
ACSF2 ligates CoA-SH to MCFA (Canis familiaris)
ACSF2 ligates CoA-SH to MCFA (Danio rerio)
ACSF2 ligates CoA-SH to MCFA (Dictyostelium discoideum)
ACSF2 ligates CoA-SH to MCFA (Drosophila melanogaster)
ACSF2 ligates CoA-SH to MCFA (Gallus gallus)
ACSF2 ligates CoA-SH to MCFA (Mus musculus)
ACSF2 ligates CoA-SH to MCFA (Rattus norvegicus)
ACSF2 ligates CoA-SH to MCFA (Sus scrofa)
ACSF2 ligates CoA-SH to MCFA (Xenopus tropicalis)
Authored
Jassal, B  (2015-05-26)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-26)
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