Acyl-coenzyme A synthetases (ACSs) catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid metabolism. Mitochondrial acyl-CoA synthetase family member 2 (ACSF2) preferentially ligates CoA-SH to medium-chain fatty acids (MCFA), around C8 in length (Watkins et al. 2007).
Pevsner, J, Jia, Z, Watkins, PA, Maiguel, D
long-chain fatty acid-CoA ligase activity of ACSF2 [mitochondrial matrix]
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