Acyl-CoA dehydrogenase family member 10 (ACAD10) is a mitochondrial enzyme that can catalyse the alpha, beta-dehydrogenation of acyl-CoA esters. ACAD10 shows highest expression in foetal brain and is shown to be active only on S-2-methylpentadecenoyl-CoA (S-2MPDA-CoA), a C15 acyl-CoA. The S isomer is dehydrogenated to its respective 2,3-dehydroacyl-CoA product, S-2methyl-2,3-dehydropentadecenoyl-CoA (S-2MDPDA) (He et al. 2011).
Van Veldhoven, PP,
acyl-CoA dehydrogenase activity of ACAD10 [mitochondrial matrix]