ACAD10 dehydrogenates S-2MPDA-CoA

Stable Identifier
R-HSA-5695980
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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ACAD10 dehydrogenates S-2MPDA-CoA
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Acyl-CoA dehydrogenase family member 10 (ACAD10) is a mitochondrial enzyme that can catalyse the alpha, beta-dehydrogenation of acyl-CoA esters. ACAD10 shows highest expression in foetal brain and is shown to be active only on S-2-methylpentadecenoyl-CoA (S-2MPDA-CoA), a C15 acyl-CoA. The S isomer is dehydrogenated to its respective 2,3-dehydroacyl-CoA product, S-2methyl-2,3-dehydropentadecenoyl-CoA (S-2MDPDA) (He et al. 2011).
Literature References
PubMed ID Title Journal Year
21237683 Identification and characterization of new long chain acyl-CoA dehydrogenases

He, M, Pei, Z, Mohsen, AW, Watkins, P, Murdoch, G, Van Veldhoven, PP, Ensenauer, R, Vockley, J

Mol. Genet. Metab. 2011
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Catalyst Activity

acyl-CoA dehydrogenase activity of ACAD10 [mitochondrial matrix]

Physical Entity
ACAD10 [mitochondrial matrix] (Homo sapiens)
Activity
acyl-CoA dehydrogenase activity (GO:0003995)
Orthologous Events
ACAD10 dehydrogenates S-2MPDA-CoA (Bos taurus)
ACAD10 dehydrogenates S-2MPDA-CoA (Caenorhabditis elegans)
ACAD10 dehydrogenates S-2MPDA-CoA (Mus musculus)
ACAD10 dehydrogenates S-2MPDA-CoA (Sus scrofa)
Authored
Jassal, B  (2015-05-26)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-26)
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