ABHD4 hydrolyses NAPE

Stable Identifier
R-HSA-5694583
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Abhydrolase domain-containing protein 4 (ABHD4) is a regulator of endocannabinoid signalling and suppressor of tumor growth. Its physiological substrates are both N-acyl phosphatidylethanolamine (NAPE) and a wide range of lysoNAPEs. Shown here, ANHD4 mediates the hydrolysis of NAPE to glycerophospho-arachidonyl ethanolamine (GPAEA), an endocannabanoid (Simon & Cravatt 2006).

Literature References
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Catalyst Activity
Catalyst Activity
Title
hydrolase activity of ABHD4 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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