Reactome | A4GNT transfers GlcNAc to core 2 mucins

A4GNT transfers GlcNAc to core 2 mucins

Stable Identifier

R-HSA-5694487

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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Alpha-1,4-N-acetylglucosaminyltransferase (A4GNT) can catalyse the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched mucins, creating an alpha1,4-linkage with beta-Gal residues (arbitrarily named Core 2a mucins) (Nakayama et al. 1999, Zhang et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11304796	Immunohistochemical demonstration of alpha1,4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1,4Galbeta residues in human gastrointestinal mucosa Hidaka, E, Ota, H, Zhang, MX, Fukuda, M, Yan, J, Kubota, S, Nakayama, J	J. Histochem. Cytochem.	2001
10430883	Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin Fukuda, M, Ito, S, Yeh, JC, Misra, AK, Katsuyama, T, Nakayama, J	Proc. Natl. Acad. Sci. U.S.A.	1999