Phospholipase ABHD3 selectively cleaves medium-chain and oxidatively-truncated phospholipids, having much higher phospholipase activity toward C14-containing phosphatidylcholines such as lysophosphatidylcholine (LPC(14:0)) and producing 1-acylglycerophosphocholine (1AGPC) (Long et al. 2011). ABHD3 is ubiquitously expressed with highest expression in brain and small intestine (Lord et al. 2013).
Thomas, G, Brown, JM, Lord, CC
Cravatt, BF, Wang, C, Cisar, JS, Milliken, D, Trauger, SA, Long, JZ, Niessen, S, Siuzdak, G
phospholipase A1 activity of ABHD3 [plasma membrane]
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