ABHD3 hydrolyses LPC(14:0) to 1AGPC

Stable Identifier
R-HSA-5694485
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phospholipase ABHD3 selectively cleaves medium-chain and oxidatively-truncated phospholipids, having much higher phospholipase activity toward C14-containing phosphatidylcholines such as lysophosphatidylcholine (LPC(14:0)) and producing 1-acylglycerophosphocholine (1AGPC) (Long et al. 2011). ABHD3 is ubiquitously expressed with highest expression in brain and small intestine (Lord et al. 2013).

Literature References
PubMed ID Title Journal Year
21926997 Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids

Long, JZ, Cisar, JS, Milliken, D, Niessen, S, Wang, C, Trauger, SA, Siuzdak, G, Cravatt, BF

Nat. Chem. Biol. 2011
23328280 Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism

Lord, CC, Thomas, G, Brown, JM

Biochim. Biophys. Acta 2013
Participants
Participates
Catalyst Activity

phospholipase A1 activity of ABHD3 [plasma membrane]

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