Reactome | ABHD3 hydrolyses LPC(14:0) to 1AGPC

ABHD3 hydrolyses LPC(14:0) to 1AGPC

Stable Identifier

R-HSA-5694485

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Phospholipase ABHD3 selectively cleaves medium-chain and oxidatively-truncated phospholipids, having much higher phospholipase activity toward C14-containing phosphatidylcholines such as lysophosphatidylcholine (LPC(14:0)) and producing 1-acylglycerophosphocholine (1AGPC) (Long et al. 2011). ABHD3 is ubiquitously expressed with highest expression in brain and small intestine (Lord et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23328280	Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism Lord, CC, Thomas, G, Brown, JM	Biochim. Biophys. Acta	2013
21926997	Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids Long, JZ, Cisar, JS, Milliken, D, Niessen, S, Wang, C, Trauger, SA, Siuzdak, G, Cravatt, BF	Nat. Chem. Biol.	2011