Reactome | ABHD6 [plasma membrane]

ABHD6 [plasma membrane]

Stable Identifier

R-HSA-5694483

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

fullName evidence="5"Monoacylglycerol lipase ABHD6 ecNumber evidence="4"3.1.1.23/ecNumber, ABHD6_HUMAN

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Effects of PIP2 hydrolysis (Homo sapiens)
    - Arachidonate production from DAG (Homo sapiens)
      - ABHD6,12 hydrolyse 3AG (Homo sapiens)
        
        ABHD6,12 [plasma membrane] (Homo sapiens)
        
        ABHD6 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Effects of PIP2 hydrolysis (Homo sapiens)
        
        Arachidonate production from DAG (Homo sapiens)
        
        ABHD6,12 hydrolyse 3AG (Homo sapiens)
        
        ABHD6,12 [plasma membrane] (Homo sapiens)
        
        ABHD6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BV23 ABHD6

Gene Names

ABHD6

Chain

chain:1-337

Reference Genes

BioGPS Gene:57406 ABHD6

COSMIC (genes):ABHD6 ABHD6

CTD Gene:57406 ABHD6

dbSNP Gene:57406 ABHD6

ENSEMBL:ENSG00000163686 ABHD6

HGNC:21398 ABHD6

KEGG:hsa:57406 ABHD6

Monarch:57406 ABHD6

NCBI Gene:57406 ABHD6

UCSC:Q9BV23 ABHD6

Reference Transcript

Other Identifiers

11723550_a_at

11752859_a_at

16942167

221552_3p_at

221552_PM_at

221552_at

221679_PM_s_at

221679_s_at

2626098

2626099

2626100

2626101

2626102

2626105

2626106

2626107

2626113

2626115

2626117

2626118

2626119

2626120

2626121

2626122

2626129

2626130

2626131

2626132

2626133

2626134

2626136

44460_r_at

45288_PM_at

45288_at

57406

8080762

A_14_P125786

A_23_P211850

GE52978

GO:0003824

GO:0004620

GO:0005515

GO:0005739

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005886

GO:0006629

GO:0009395

GO:0016020

GO:0016787

GO:0019369

GO:0030336

GO:0031410

GO:0031902

GO:0031966

GO:0032281

GO:0043226

GO:0045211

GO:0046464

GO:0046889

GO:0047372

GO:0052651

GO:0060292

GO:0098978

GO:0098982

GO:0099178

GO:0120163

GO:1901135

GO:2000124

GO:2001311

HMNXSV003002675

ILMN_1706344

PH_hs_0022106

TC03000376.hg

g12804562_3p_at

g12804562_3p_s_at

Participates

as a member of

ABHD6,12 [plasma membrane] (Homo sapiens)

Inferred To

ABHD6 [plasma membrane] (Bos taurus)

ABHD6 [plasma membrane] (Canis familiaris)

ABHD6 [plasma membrane] (Gallus gallus)

ABHD6 [plasma membrane] (Sus scrofa)

Abhd6 [plasma membrane] (Mus musculus)

Abhd6 [plasma membrane] (Rattus norvegicus)

abhd6 [plasma membrane] (Xenopus tropicalis)

LDH1 [plasma membrane] (Saccharomyces cerevisiae)

Cross References

Guide to Pharmacology - Targets

2919

ENSEMBL

ENSG00000163686, ENST00000478253, ENSP00000420315, ENST00000295962, ENSP00000295962

OpenTargets

ENSG00000163686

ZINC - FDA approved

ABHD6_HUMAN

ZINC - Substances

ABHD6_HUMAN

ZINC target

Q9BV23

PRO

Q9BV23

PDB

7OTS

GeneCards

ABHD6

HPA

ENSG00000163686-ABHD6

Pharos - Targets

Q9BV23

ZINC - Predictions - Purchasable

ABHD6_HUMAN

HMDB Protein

HMDBP11599

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2