ABHD6,12 hydrolyse 3AG

Stable Identifier
R-HSA-5694462
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Three members of the serine hydrolase family are involved in the degradation of the endocannabinoid 2-arachidonoylyglycerol (C20:4) (2AG). The major enzymatic route for 2AG inactivation is via hydrolysis, generating arachidonic acid (AA) and glycerol. Two of the serine hydrolases, monoacylglycerol lipases 6 and 12 (ABHD6 and 12), have preference for the 3-acyl isomer of arachidonoylyglycerol (3AG) although they can also hydrolyse 2AG at a lower rate (Navia-Paldanius et al. 2012, Savinainen et al. 2012).

Literature References
PubMed ID Title Journal Year
22969151 Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

Navia-Paldanius, D, Savinainen, JR, Laitinen, JT

J. Lipid Res. 2012
21418147 The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

Savinainen, JR, Saario, SM, Laitinen, JT

Acta Physiol (Oxf) 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acylglycerol lipase activity of ABHD6,12 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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