Reactome | BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle

BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle

Stable Identifier

R-HSA-5694446

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)

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BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle

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After displacement of the COPII coat, a tetrameric SNAREpin forms between the v-SNARE and the three t-SNARE proteins (Hay et al, 1997; Hay et al, 1998; Hui et al, 1997; Bentley et al, 2006; reviewed in Hong and Lev 2014). This interaction is promoted by the tethering factor USO1 and by the STX5-interacting protein SCFD1 (Wang et al, 2014; Dascher and Balch, 1996; Cao and Barlowe 2000; Flanagan and Barlowe, 2006; reviewed in Lord et al, 2013). The zippering of the SNAREpin provides the mechanical force that drives membrane fusion, releasing cargo into the acceptor compartment (reviewed in Sudhof and Rothman, 2009).

Literature References

PubMed ID	Title	Journal	Year
16303754	Cysteine-disulfide cross-linking to monitor SNARE complex assembly during endoplasmic reticulum-Golgi transport Flanagan, JJ, Barlowe, C	J. Biol. Chem.	2006
9647643	Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs Hay, JC, Klumperman, J, Oorschot, V, Steegmaier, M, Kuo, CS, Scheller, RH	J. Cell Biol.	1998
24119662	Tethering the assembly of SNARE complexes Hong, W, Lev, S	Trends Cell Biol.	2014
8663406	Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum to Golgi transport Dascher, C, Balch, WE	J. Biol. Chem.	1996
25406594	p115-SNARE interactions: a dynamic cycle of p115 binding monomeric SNARE motifs and releasing assembled bundles Wang, T, Grabski, R, Sztul, E, Hay, JC	Traffic	2015
19164740	Membrane fusion: grappling with SNARE and SM proteins Südhof, TC, Rothman, JE	Science	2009
23378591	The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi Lord, C, Ferro-Novick, S, Miller, EA	Cold Spring Harb Perspect Biol	2013
9307973	An isoform of the Golgi t-SNARE, syntaxin 5, with an endoplasmic reticulum retrieval signal Hui, N, Nakamura, N, Sönnichsen, B, Shima, DT, Nilsson, T, Warren, G	Mol. Biol. Cell	1997
9094723	Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells Hay, JC, Chao, DS, Kuo, CS, Scheller, RH	Cell	1997
10747087	Asymmetric requirements for a Rab GTPase and SNARE proteins in fusion of COPII vesicles with acceptor membranes Cao, X, Barlowe, C	J. Cell Biol.	2000
17038314	SNARE status regulates tether recruitment and function in homotypic COPII vesicle fusion Bentley, M, Liang, Y, Mullen, K, Xu, D, Sztul, E, Hay, JC	J. Biol. Chem.	2006