CNIH2 and 3 are members of the ERV14 family of transmembrane proteins with a role in chaperoning cargo out of the ER (reviewed in Dancourt and Barlowe, 2010). CNIH2 and 3 bind to components of the AMPA-type glutamate receptor complex, including GRIA1 in the ER and facilitate their trafficking to the plasma membrane. CNIH2 and 3 may play additional roles at the cell surface modulating the function of the channels (Shi et al, 2010; Schwenk et al, 2009).
Dancourt, J, Barlowe, C
Zolles, G, Heimrich, B, Schulte, U, Bildl, W, Schwenk, J, Fakler, B, Kulik, A, Klöcker, N, Jonas, P, Chisaka, O, Harmel, N
Roche, KW, Suh, YH, Nicoll, RA, Isozaki, K, Milstein, AD, Shi, Y, Schmid, SM
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