Reactome | CNIH2,3 bind GRIA1

CNIH2,3 bind GRIA1

Stable Identifier

R-HSA-5694442

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        CNIH2,3 bind GRIA1 (Homo sapiens)

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CNIH2 and 3 are members of the ERV14 family of transmembrane proteins with a role in chaperoning cargo out of the ER (reviewed in Dancourt and Barlowe, 2010). CNIH2 and 3 bind to components of the AMPA-type glutamate receptor complex, including GRIA1 in the ER and facilitate their trafficking to the plasma membrane. CNIH2 and 3 may play additional roles at the cell surface modulating the function of the channels (Shi et al, 2010; Schwenk et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
20533886	Protein sorting receptors in the early secretory pathway Dancourt, J, Barlowe, C	Annu. Rev. Biochem.	2010
19265014	Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors Zolles, G, Heimrich, B, Schulte, U, Bildl, W, Schwenk, J, Fakler, B, Kulik, A, Klöcker, N, Jonas, P, Chisaka, O, Harmel, N	Science	2009
20805473	Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating Roche, KW, Suh, YH, Nicoll, RA, Isozaki, K, Milstein, AD, Shi, Y, Schmid, SM	Proc. Natl. Acad. Sci. U.S.A.	2010