COPII coat binds TRAPPCII and RAB1:GDP

Stable Identifier
R-HSA-5694439
Type
Reaction
Species
Homo sapiens
Compartment
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TRAPPC is a multi-subunit tethering complex that facilitates ER-to-Golgi traffic (reviewed in Barrowman et al, 2010; Brunet and Sacher, 2014). TRAPPC is a guanine-nucleotide exchange factor for RAB1 and is recruited to ER-derived vesicles by virtue of an interaction between the TRAPPC component TRAPPC3 and the coat protein SEC23 (Cai et al, 2007; Lord et al, 2011).

Literature References
PubMed ID Title Journal Year
17287728 TRAPPI tethers COPII vesicles by binding the coat subunit Sec23

Fu, C, Ferro-Novick, S, Yu, S, Cai, H, Menon, S, Lazarova, D, Cai, Y, Hay, JC, Reinisch, K

Nature 2007
24917561 In sickness and in health: the role of TRAPP and associated proteins in disease

Sacher, M, Brunet, S

Traffic 2014
21532587 Sequential interactions with Sec23 control the direction of vesicle traffic

Ghassemian, M, Ghosh, P, Bhandari, D, Ferro-Novick, S, Menon, S, Nycz, D, Lord, C, Hay, J

Nature 2011
20966969 TRAPP complexes in membrane traffic: convergence through a common Rab

Bhandari, D, Ferro-Novick, S, Barrowman, J, Reinisch, K

Nat. Rev. Mol. Cell Biol. 2010
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