Reactome | COPII coat binds TRAPPCII and RAB1:GDP

COPII coat binds TRAPPCII and RAB1:GDP

Stable Identifier

R-HSA-5694439

Type

Reaction [binding]

Species

Homo sapiens

Compartment

COPII-coated ER to Golgi transport vesicle

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)

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TRAPPC is a multi-subunit tethering complex that facilitates ER-to-Golgi traffic (reviewed in Barrowman et al, 2010; Brunet and Sacher, 2014). TRAPPC is a guanine-nucleotide exchange factor for RAB1 and is recruited to ER-derived vesicles by virtue of an interaction between the TRAPPC component TRAPPC3 and the coat protein SEC23 (Cai et al, 2007; Lord et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
17287728	TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 Cai, H, Yu, S, Menon, S, Cai, Y, Lazarova, D, Fu, C, Reinisch, K, Hay, JC, Ferro-Novick, S	Nature	2007
24917561	In sickness and in health: the role of TRAPP and associated proteins in disease Brunet, S, Sacher, M	Traffic	2014
21532587	Sequential interactions with Sec23 control the direction of vesicle traffic Lord, C, Bhandari, D, Menon, S, Ghassemian, M, Nycz, D, Hay, J, Ghosh, P, Ferro-Novick, S	Nature	2011
20966969	TRAPP complexes in membrane traffic: convergence through a common Rab Barrowman, J, Bhandari, D, Reinisch, K, Ferro-Novick, S	Nat. Rev. Mol. Cell Biol.	2010