Reactome | COPII coat binds TRAPPCII and RAB1:GDP

COPII coat binds TRAPPCII and RAB1:GDP

Stable Identifier

R-HSA-5694439

Type

Reaction [binding]

Species

Homo sapiens

Compartment

COPII-coated ER to Golgi transport vesicle

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)

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TRAPPC is a multi-subunit tethering complex that facilitates ER-to-Golgi traffic (reviewed in Barrowman et al, 2010; Brunet and Sacher, 2014). TRAPPC is a guanine-nucleotide exchange factor for RAB1 and is recruited to ER-derived vesicles by virtue of an interaction between the TRAPPC component TRAPPC3 and the coat protein SEC23 (Cai et al, 2007; Lord et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
17287728	TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 Fu, C, Ferro-Novick, S, Yu, S, Cai, H, Menon, S, Lazarova, D, Cai, Y, Hay, JC, Reinisch, K	Nature	2007
24917561	In sickness and in health: the role of TRAPP and associated proteins in disease Sacher, M, Brunet, S	Traffic	2014
21532587	Sequential interactions with Sec23 control the direction of vesicle traffic Ghassemian, M, Ghosh, P, Bhandari, D, Ferro-Novick, S, Menon, S, Nycz, D, Lord, C, Hay, J	Nature	2011
20966969	TRAPP complexes in membrane traffic: convergence through a common Rab Bhandari, D, Ferro-Novick, S, Barrowman, J, Reinisch, K	Nat. Rev. Mol. Cell Biol.	2010