COPII coat binds TRAPPCII and RAB1:GDP

Stable Identifier
R-HSA-5694439
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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TRAPPC is a multi-subunit tethering complex that facilitates ER-to-Golgi traffic (reviewed in Barrowman et al, 2010; Brunet and Sacher, 2014). TRAPPC is a guanine-nucleotide exchange factor for RAB1 and is recruited to ER-derived vesicles by virtue of an interaction between the TRAPPC component TRAPPC3 and the coat protein SEC23 (Cai et al, 2007; Lord et al, 2011).

Literature References
PubMed ID Title Journal Year
24917561 In sickness and in health: the role of TRAPP and associated proteins in disease

Brunet, S, Sacher, M

Traffic 2014
17287728 TRAPPI tethers COPII vesicles by binding the coat subunit Sec23

Cai, H, Yu, S, Menon, S, Cai, Y, Lazarova, D, Fu, C, Reinisch, K, Hay, JC, Ferro-Novick, S

Nature 2007
21532587 Sequential interactions with Sec23 control the direction of vesicle traffic

Lord, C, Bhandari, D, Menon, S, Ghassemian, M, Nycz, D, Hay, J, Ghosh, P, Ferro-Novick, S

Nature 2011
20966969 TRAPP complexes in membrane traffic: convergence through a common Rab

Barrowman, J, Bhandari, D, Reinisch, K, Ferro-Novick, S

Nat. Rev. Mol. Cell Biol. 2010
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