MIA2 and MIA3 dissociate from procollagen VII vesicle

Stable Identifier
R-HSA-5694436
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Unlike other cargo receptors, MIA2 (also known as CTAGE5) and MIA3 are not packaged into COPII vesicles but remain behind in the ER membrane. Dissociation of MIA3 from procollagen and from inner coat proteins SEC23 and SEC24 is thought to trigger recruitment of the outer coat proteins SEC13/31, allowing COPII coat maturation (Saito et al, 2009; Saito et al, 2011; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).

Literature References
PubMed ID Title Journal Year
25619253 Procollagen export from the endoplasmic reticulum

Malhotra, V, Erlmann, P, Nogueira, C

Biochem. Soc. Trans. 2015
21878990 Protein export at the ER: loading big collagens into COPII carriers

Malhotra, V, Erlmann, P

EMBO J 2011
19269366 TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites

Saito, K, Chen, M, Bard, F, Chen, S, Zhou, H, Woodley, D, Polischuk, R, Schekman, R, Malhotra, V

Cell 2009
21525241 cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites

Saito, K, Yamashiro, K, Ichikawa, Y, Erlmann, P, Kontani, K, Malhotra, V, Katada, T

Mol. Biol. Cell 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created