Reactome | MIA2 and MIA3 dissociate from procollagen VII vesicle

MIA2 and MIA3 dissociate from procollagen VII vesicle

Stable Identifier

R-HSA-5694436

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        MIA2 and MIA3 dissociate from procollagen VII vesicle (Homo sapiens)

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MIA2 and MIA3 dissociate from procollagen VII vesicle

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Unlike other cargo receptors, MIA2 (also known as CTAGE5) and MIA3 are not packaged into COPII vesicles but remain behind in the ER membrane. Dissociation of MIA3 from procollagen and from inner coat proteins SEC23 and SEC24 is thought to trigger recruitment of the outer coat proteins SEC13/31, allowing COPII coat maturation (Saito et al, 2009; Saito et al, 2011; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
21878990	Protein export at the ER: loading big collagens into COPII carriers Malhotra, V, Erlmann, P	EMBO J	2011
25619253	Procollagen export from the endoplasmic reticulum Erlmann, P, Nogueira, C, Malhotra, V	Biochem. Soc. Trans.	2015
19269366	TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites Polischuk, R, Saito, K, Chen, M, Schekman, R, Chen, S, Bard, F, Woodley, D, Malhotra, V, Zhou, H	Cell	2009
21525241	cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites Erlmann, P, Saito, K, Yamashiro, K, Katada, T, Malhotra, V, Kontani, K, Ichikawa, Y	Mol. Biol. Cell	2011