MIA2 and MIA3 dissociate from procollagen VII vesicle

Stable Identifier
Reaction [dissociation]
Homo sapiens
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Unlike other cargo receptors, MIA2 (also known as CTAGE5) and MIA3 are not packaged into COPII vesicles but remain behind in the ER membrane. Dissociation of MIA3 from procollagen and from inner coat proteins SEC23 and SEC24 is thought to trigger recruitment of the outer coat proteins SEC13/31, allowing COPII coat maturation (Saito et al, 2009; Saito et al, 2011; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).
Literature References
PubMed ID Title Journal Year
21878990 Protein export at the ER: loading big collagens into COPII carriers

Malhotra, V, Erlmann, P

EMBO J 2011
25619253 Procollagen export from the endoplasmic reticulum

Erlmann, P, Nogueira, C, Malhotra, V

Biochem. Soc. Trans. 2015
19269366 TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites

Polischuk, R, Saito, K, Chen, M, Schekman, R, Chen, S, Bard, F, Woodley, D, Malhotra, V, Zhou, H

Cell 2009
21525241 cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites

Erlmann, P, Saito, K, Yamashiro, K, Katada, T, Malhotra, V, Kontani, K, Ichikawa, Y

Mol. Biol. Cell 2011
Orthologous Events
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