Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors

Stable Identifier
R-HSA-5694431
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Secretion of the clotting factor precursors Factor V and Factor VIII from the ER depends on interaction with a Ca2+-dependent receptor complex of LMAN1 and its soluble interaction partner MCFD2 (Nyfeler et al, 2006; reviewed in Zheng and Zhang, 2013; Dancourt and Barlowe, 2010).

Literature References
PubMed ID Title Journal Year
20533886 Protein sorting receptors in the early secretory pathway

Dancourt, J, Barlowe, C

Annu. Rev. Biochem. 2010
17010120 Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex

Nyfeler, B, Zhang, B, Ginsburg, D, Kaufman, RJ, Hauri, HP

Traffic 2006
23852824 Combined deficiency of coagulation factors V and VIII: an update

Zheng, C, Zhang, B

Semin. Thromb. Hemost. 2013
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created