LMAN family proteins bind glycosylated cargo

Stable Identifier
R-HSA-5694428
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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LMAN1, also known as ERGIC-53, is a transmembrane receptor that binds to high-mannose containing soluble glycoproteins in the ER and helps package them into COPII vesicles for trafficking to the ERGIC and Golgi. Identified cargo include SERPINA (alpha1-antitrypsin) and the cathepsins CTSC and CTSZ, among others (Nyefeler et al, 2008; Appenzeller et al, 1999; reviewed in Hauri et al, 2000; Szul and Sztul, 2011). LMAN1 itself is concentrated into COPII vesicles through interaction with components of the COPII coat (Kappeler et al, 1997; reviewed in Dancourt and Barlowe, 2010). Other LMAN family proteins, which include LMANL1, LMAN2 and LMAN2L, also bind glycosylated ER cargo proteins, although the lectin specificities vary (Kamiya et al, 2005; Kamiya et al, 2007; Reiterer et al, 2010; reviewed in Dancourt and Barlowe, 2010).

Literature References
PubMed ID Title Journal Year
10652252 ERGIC-53 and traffic in the secretory pathway

Hauri, HP, Kappeler, F, Andersson, H, Appenzeller, C

J. Cell. Sci. 2000
18025080 Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL, and VIP36

Kamiya, Y, Kamiya, D, Yamamoto, K, Nyfeler, B, Hauri, HP, Kato, K

J. Biol. Chem. 2008
22013193 COPII and COPI traffic at the ER-Golgi interface

Szul, T, Sztul, E

Physiology (Bethesda) 2011
16129679 Sugar-binding properties of VIP36, an intracellular animal lectin operating as a cargo receptor

Kamiya, Y, Yamaguchi, Y, Takahashi, N, Arata, Y, Kasai, K, Ihara, Y, Matsuo, I, Ito, Y, Yamamoto, K, Kato, K

J. Biol. Chem. 2005
20533886 Protein sorting receptors in the early secretory pathway

Dancourt, J, Barlowe, C

Annu. Rev. Biochem. 2010
10559958 The lectin ERGIC-53 is a cargo transport receptor for glycoproteins

Appenzeller, C, Andersson, H, Kappeler, F, Hauri, HP

Nat. Cell Biol. 1999
20477988 Role of the lectin VIP36 in post-ER quality control of human alpha1-antitrypsin

Reiterer, V, Nyfeler, B, Hauri, HP

Traffic 2010
9395526 The recycling of ERGIC-53 in the early secretory pathway. ERGIC-53 carries a cytosolic endoplasmic reticulum-exit determinant interacting with COPII

Kappeler, F, Klopfenstein, DR, Foguet, M, Paccaud, JP, Hauri, HP

J. Biol. Chem. 1997
18283111 Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin

Nyfeler, B, Reiterer, V, Wendeler, MW, Stefan, E, Zhang, B, Michnick, SW, Hauri, HP

J. Cell Biol. 2008
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