MIA3 binds procollagen VII

Stable Identifier
R-HSA-5694427
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Procollagen VII trimers, which are too large for standard COPII vesicles, are packaged into larger transport vesicles through interaction with the transmembrane accessory proteins MIA3 (also known as TANGO1) and MIA2 (also known as CTAGE5). MIA3 interacts with collagen through its lumenal SH3 domain and interacts with SEC23 and SEC24 through the proline rich domain (Saito et al, 2009; reviewed in Malhotra and Erlmann, 2011; Malhotra et al, 2015).

Literature References
PubMed ID Title Journal Year
25619253 Procollagen export from the endoplasmic reticulum

Malhotra, V, Erlmann, P, Nogueira, C

Biochem. Soc. Trans. 2015
21878990 Protein export at the ER: loading big collagens into COPII carriers

Malhotra, V, Erlmann, P

EMBO J 2011
19269366 TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites

Saito, K, Chen, M, Bard, F, Chen, S, Zhou, H, Woodley, D, Polischuk, R, Schekman, R, Malhotra, V

Cell 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created