NSF and SNAPs bind cis-SNARE complex

Stable Identifier
R-HSA-5694423
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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After membrane fusion, the cis-SNARE complex is dissociated in an ATP-dependent fashion by the AAA protein NSF in conjunction with SNAP proteins (Mayer et al, 1996; Sollner et al, 1993; reviewed in Jahn and Scheller, 2006; Sudhof and Rothman, 2009).

Literature References
PubMed ID Title Journal Year
8221884 A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

Söllner, T, Bennett, MK, Whiteheart, SW, Scheller, RH, Rothman, JE

Cell 1993
8620540 Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles

Mayer, A, Wickner, W, Haas, A

Cell 1996
19164740 Membrane fusion: grappling with SNARE and SM proteins

Südhof, TC, Rothman, JE

Science 2009
16912714 SNAREs--engines for membrane fusion

Jahn, R, Scheller, RH

Nat. Rev. Mol. Cell Biol. 2006
Participants
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Orthologous Events
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Created